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Showing 1–4 of 4 results
Advanced filters: Author: Ganesh Agam Clear advanced filters

  • Hsp90 is a molecular chaperone important for protein homeostasis. Here, the authors show that the conformational transitions during the Hsp90 ATPase cycle are conserved from yeast to humans, but a few mutations alter cycle timing and dynamics.

    • Stefan Riedl
    • Ecenaz Bilgen
    • Johannes Buchner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Here, using single molecule FRET, the unfolding and folding of a discontinuous two-domain protein was studied. The authors find that a dynamic, intermediate population entropically limits the rate of folding while the order of domain folding is kept in a slow-folding mutant.

    • Ganesh Agam
    • Anders Barth
    • Don C. Lamb
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The ER-resident Hsp70 BiP is regulated by NEF Bap. The interactions between BiP and Bap are now dissected using biochemistry, molecular modeling and smFRET approaches, revealing that Bap affects both domains of BiP, to coordinate release of substrate and nucleotide.

    • Mathias Rosam
    • Daniela Krader
    • Johannes Buchner
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 90-100