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Showing 1–2 of 2 results
Advanced filters: Author: Ganesh V. Pusapati Clear advanced filters

  • Tubulin post-translational modifications (PTMs) occur spatiotemporally throughout cells, therefore assessing the physiological roles in specific subcellular compartments has been challenging. Here the authors develop a method to rapidly deplete tubulin glutamylation inside the primary cilia by targeting an engineered deglutamylase to the axoneme.

    • Shi-Rong Hong
    • Cuei-Ling Wang
    • Yu-Chun Lin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Naturally occurring tumour-binding IgG antibodies are shown to initiate the rejection of allogeneic tumours, whereby Fc-receptor-mediated uptake of tumour immune complexes into dendritic cells activates tumour-reactive T cells, and intra-tumoral injection of allogeneic IgG together with dendritic cell adjuvants induces systemic T-cell-mediated antitumour responses.

    • Yaron Carmi
    • Matthew H. Spitzer
    • Edgar G. Engleman
    Research
    Nature
    Volume: 521, P: 99-104