A catalytic method for the enantioselective and C4-selective functionalization of pyridine derivatives is yet to be developed. Here the authors report an efficient method for the asymmetric β-pyridylations of enals that involve N-heterocyclic carbene (NHC) catalysis with excellent control over enantioselectivity and pyridyl C4-selectivity.
- Hangyeol Choi
- Gangadhar Rao Mathi
- Sungwoo Hong