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Showing 1–5 of 5 results
Advanced filters: Author: Gangshun Yi Clear advanced filters

  • In this Tools of the Trade article, Yi and Mamalis (Gilbert and Davis labs) discuss the development of Di-Gembodies, innovative constructs designed to overcome key challenges in applying cryo-electron microscopy to small proteins that are otherwise difficult to resolve.

    • Gangshun Yi
    • Dimitrios Mamalis
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 27, P: 174

  • Disulfide-based dimerization of modified identical and heterologous nanobody scaffolds enables higher-order assembly for high-resolution cryo-electron microscopy structure determination that is widely applicable to small protein targets.

    • Gangshun Yi
    • Dimitrios Mamalis
    • Robert J. C. Gilbert
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 22, P: 69-76

  • CryoEM sample preparation for low abundance or preferentially oriented particles remains challenging. Jianbing Ma et al. develop the mspSA affinity-grid method that enriches particles on EM grids and reduces air-water interface exposure, demonstrating usefulness for several difficult samples.

    • Jianbing Ma
    • Gangshun Yi
    • Peijun Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The Wnt receptor Frizzled (FZD) family is crucial for both canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signalling. Here, the authors present the structures of FZD3 in complex with extracellular and intracellular binding nanobodies (Nbs), elucidating extracellular and intracellular interaction surfaces of functional and potentially therapeutic significance.

    • James Hillier
    • Yuguang Zhao
    • E. Yvonne Jones
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Here, the authors show that cytoplasmic uridylyltransferases TUT7 and TUT4 bind let-7 pre-miRNA by alternative means in the absence and presence of Lin28A, which directly interacts with both RNA and enzyme to convert from a distributive to a processive mode of action.

    • Gangshun Yi
    • Mingda Ye
    • Robert J. C. Gilbert
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1426-1438