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Showing 1–2 of 2 results
Advanced filters: Author: Garth W. Devlin Clear advanced filters
  • Gonzalez et al. use a viral evolutionary approach to generate cross-species compatible AAV (ccAAVs) vectors. They describe a highly potent new variant, AAV.cc47, with enhanced transduction efficiency over AAV serotype 9 and show its efficacy in different mouse models, pigs and non-human primates.

    • Trevor J. Gonzalez
    • Katherine E. Simon
    • Aravind Asokan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17
  • Adeno-associated viruses can be secreted in a pre-lytic manner as free or extracellular vesicle (EV)-associated particles. Here, Elmore et al. show that the recently identified membrane-associated accessory protein (MAAP) functions as an AAV egress factor via association to EVs.

    • Zachary C. Elmore
    • L. Patrick Havlik
    • Aravind Asokan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13