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Natural and inducible T_H17 cells are regulated differently by Akt and mTOR pathways

The Akt-mTOR axis influences cell activation, differentiation and metabolism. Jordan and colleagues show that thymic and inducible T_H17 cells exhibit different requirements for mTORC1 and mTORC2 as well as Akt isoforms.

Jiyeon S Kim
Tammarah Sklarz
Gary A Koretzky
Research05 May 2013
Nature Immunology

Volume: 14, P: 611-618
Communicating science effectively in times of crisis: time for reflection

Gary Koretzky, who was president of the American Association of Immunologists from 2021 to 2022, shares his thoughts on the responsibility of scientists to make science more accessible to a broad public, and reflects on lessons learned during the pandemic.

Gary Koretzky
Comments & Opinion16 Nov 2023
Nature Reviews Immunology

Volume: 23, P: 781-782
Antigen receptor signaling: the Tuscan connection

At the first meeting of the new three-part EMBO Conference series on “Signaling in the immune system,” immunologists presented key findings and highlighted new questions and emerging trends.

Cosima T Baldari
Gary A Koretzky
News & Views01 Aug 2007
Nature Immunology

Volume: 8, P: 787-790
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

Gary A. Koretzky
Joel Picus
Arthur. Weiss
Research05 Jul 1990
Nature

Volume: 346, P: 66-68
CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur M. Krieg
Ae-Kyung Yi
Dennis M. Klinman
Research06 Apr 1995
Nature

Volume: 374, P: 546-549
Lymphocyte signaling: a Tuscan affair

At the third of the three-part EMBO Conference series “Signaling in the immune system,” immunologists presented their most recent findings in this rapidly moving field and discussed new questions and emerging trends.

Cosima T Baldari
Oreste Acuto
Arthur Weiss
News & Views16 Dec 2011
Nature Immunology

Volume: 13, P: 3-6
Navigating the leukocyte signaling maze guided by Ariadne's thread

Ariadne is the legendary Minoan goddess of the Labyrinth. The term 'Ariadne's thread' is used to describe the understanding of complex issues. Immunologists attending the 5th Leukocyte Signal Transduction Workshop discussed the Ariadne's thread woven about intracellular signaling pathways.

Amnon Altman
Gary A Koretzky
Constantine D Tsoukas
News & Views01 Nov 2009
Nature Immunology

Volume: 10, P: 1134-1136
Positive and negative regulation of t-cell activation by adaptor proteins

Gary A. Koretzky
Peggy S. Myung
Reviews01 Nov 2001
Nature Reviews Immunology

Volume: 1, P: 95-107
Retraction Note: Natural and inducible T_H17 cells are regulated differently by Akt and mTOR pathways

Jiyeon S Kim
Tammarah Sklarz
Gary A Koretzky
Amendments and Corrections18 Sept 2014
Nature Immunology

Volume: 15, P: 996
CD3ɛ: PeRuSing for positive selection

How engagement of surface T cell antigen receptors 'translates' into intracellular signal cascades remains vague. Genetic and biochemical experiments now allow modification of a model linking ligation of these receptors with CD3ɛ and other cytoplasmic signal-transduction 'machinery'.

Jonathan S Maltzman
Gary A Koretzky
News & Views01 May 2008
Nature Immunology

Volume: 9, P: 457-459
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

Junko Irie-Sasaki
Takehiko Sasaki
Josef M. Penninger
Research18 Jan 2001
Nature

Volume: 409, P: 349-354
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

This article describes the recent studies that elucidate the mechanism of action of the adaptor proteins SLP76 and SLP65. It details their crucial role in signalling by immunoreceptors and integrins, as well as their further unexpected roles in vascular development and leukaemia.

Gary A. Koretzky
Farhad Abtahian
Michael A. Silverman
Reviews01 Jan 2006
Nature Reviews Immunology

Volume: 6, P: 67-78
Enhanced T cell responses due to diacylglycerol kinase ζ deficiency

Xiao-Ping Zhong
Ehmonie A Hainey
Gary A Koretzky
Research27 Jul 2003
Nature Immunology

Volume: 4, P: 882-890
Regulation of NKT cell development by SAP, the protein defective in XLP

Kim E Nichols
Jamie Hom
Paul L Stein
Research13 Feb 2005
Nature Medicine

Volume: 11, P: 340-345
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy

Benjamin A Olenchock
Rishu Guo
Xiao-Ping Zhong
Research08 Oct 2006
Nature Immunology

Volume: 7, P: 1174-1181
Integrins and ITAMs: more than just good neighbors

New data show that integrin signaling by the Syk tyrosine kinase requires adaptors, such as DAP12, that have immunoreceptor tyrosine-based activation motifs.

Mark L Kahn
Gary A Koretzky
News & Views01 Dec 2006
Nature Immunology

Volume: 7, P: 1286-1288
Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

PIKfyve is a lipid kinase essential for regulation of membrane homeostasis and vesicle trafficking along the endosomal-lysosomal pathway. Here the authors show that mice lacking PIKfyve exclusively in their platelets exhibit a systemic disorder characterized by multi-organ inflammation and thrombosis due to aberrant platelet lysosome function.

Sang H. Min
Aae Suzuki
Charles S. Abrams
Research02 Sept 2014
Nature Communications

Volume: 5, P: 1-12
Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death

Matthew B Jarpe
Christian Widmann
Gary L Johnson
Reviews22 Sept 1998
Oncogene

Volume: 17, P: 1475-1482
SAP: natural inhibitor or grand SLAM of T cell activation?

Identification of SH2D1A as the defective gene in X-linked lymphoproliferative syndrome highlighted the importance of SAP in the regulation of T cell activation. New data suggest an alternative explanation for how SAP controls signaling.

Kim E. Nichols
Gary A. Koretzky
Carl H. June
News & Views01 Aug 2001
Nature Immunology

Volume: 2, P: 665-666
Antigen receptor signaling: the Tuscan chronicles

The fourth EMBO workshop on “Lymphocyte antigen receptor and coreceptor signaling” gathered immunologists to share key findings, new questions and emerging trends in the field of cell signaling.

Cosima T Baldari
Gary Koretzky
Oreste Acuto
News & Views01 Jan 2005
Nature Immunology

Volume: 6, P: 3-5
Adaptors as central mediators of signal transduction in immune cells

Martha S. Jordan
Andrew L. Singer
Gary A. Koretzky
Reviews01 Feb 2003
Nature Immunology

Volume: 4, P: 110-116
Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?

Although the MHC class II-mediated modulation of CD4⁺ T cell responses is typically associated with dendritic cells, macrophages and B cells, other cell populations are also suggested to show such behaviour. The authors discuss these atypical antigen-presenting cells and question their relevance to immune responses in vivo.

Taku Kambayashi
Terri M. Laufer
Reviews17 Oct 2014
Nature Reviews Immunology

Volume: 14, P: 719-730
The role of the adapter molecule SLP-76 in platelet function

Barbi A Judd
Gary A Koretzky
Reviews17 Oct 2001
Oncogene

Volume: 20, P: 6291-6299

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