Insulin secretion from pancreatic b cells is tightly regulated. Using chromosome conformation capture techniques, it is now found that the insulin promoter locus forms a long-range glucose-regulated interaction with SYT8, linked here to insulin secretion. SYT8 expression is affected concordantly with changes in insulin expression, suggesting a mechanism whereby insulin expression and secretion might be coordinated.
- Zhixiong Xu
- Gang Wei
- Gary Felsenfeld
