Nature Search

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency

A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of frataxin-stimulated NFS1 activity.

Joshua D. Meisel
Pallavi R. Joshi
Vamsi K. Mootha
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 713-720
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

Jason Z. Morris
Heidi A. Tissenbaum
Gary Ruvkun
Research08 Aug 1996
Nature

Volume: 382, P: 536-539
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons

David M. Miller
Michael M. Shen
Laura Wilson
Research27 Feb 1992
Nature

Volume: 355, P: 841-845
A molecular growth industry

Gary Ruvkun
News & Views31 Dec 1992
Nature

Volume: 360, P: 711-712
The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch

Gary Ruvkun
John Giusto
Research23 Mar 1989
Nature

Volume: 338, P: 313-319
A general method for site-directed mutagenesis in prokaryotes

Gary B. Ruvkun
Frederick M. Ausubel
Research01 Jan 1981
Nature

Volume: 289, P: 85-88
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence

To identify comprehensively factors involved in RNAi and microRNA-mediated gene expression regulation, this study performed a phylogenetic analysis of 86 eukaryotic species; the candidates this approach highlighted were subjected to Bayesian analysis with transcriptional and proteomic interaction data, identifying protein orthologues of already known RNAi silencing factors, as well as other hits involved in splicing, suggesting a connection between the two processes.

Yuval Tabach
Allison C. Billi
Gary Ruvkun
Research23 Dec 2012
Nature

Volume: 493, P: 694-698
Caenorhabditis elegans has scores of homoeobox-containing genes

Thomas R. Bürglin
Michael Finney
Gary Ruvkun
Research21 Sept 1989
Nature

Volume: 341, P: 239-243
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity

FOXO transcription factors confer stress resistance and longevity in several organisms. Ruvkun and colleagues demonstrate in Caenorhabditis elegans that DAF-16 (FOXO homologue) recruits the chromatin remodeller SWI/SNF to target genes. They show that SWI/SNF is required for DAF-16-mediated functions such as dauer formation, stress resistance and increasing longevity.

Christian G. Riedel
Robert H. Dowen
Gary Ruvkun
Research21 Apr 2013
Nature Cell Biology

Volume: 15, P: 491-501
Caenorhabditis elegans pathways that surveil and defend mitochondria

A genome-wide RNA interference screen in Caenorhabditis elegans identifies 45 genes with roles in protective pathways following drug- and genetic-disruption-induced mitochondrial inhibition.

Ying Liu
Buck S. Samuel
Gary Ruvkun
Research02 Apr 2014
Nature

Volume: 508, P: 406-410
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

During fasting, cellular lipophagy is activated and lipid stores are catabolized. O’Rourke and Ruvkun identify two metabolic transcriptional regulators, MXL-3 and HLH-30, which orchestrate the adaptive response to fasting by modulating the expression of lysosomal lipases and autophagy genes. In addition, they show that these regulators can influence C. elegans aging.

Eyleen J. O’Rourke
Gary Ruvkun
Research21 Apr 2013
Nature Cell Biology

Volume: 15, P: 668-676
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans

Through RNAi screens in C. elegans, Ruvkun and colleagues identify signalling pathways that induce detoxification genes following disrupted translation, suggesting translational surveillance of toxins and virulence factors.

J. Amaranath Govindan
Elamparithi Jayamani
Gary Ruvkun
Research31 Aug 2015
Nature Cell Biology

Volume: 17, P: 1294-1303
Sequences homologous to Agrobacterium rhizogenes T-DNA in the genomes of uninfected plants

Frank F. White
David J. Garfinkel
Eugene W. Nester
Research27 Jan 1983
Nature

Volume: 301, P: 348-350
A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans

Gisela M Sandoval
Janet S Duerr
Gary Ruvkun
Research09 Apr 2006
Nature Neuroscience

Volume: 9, P: 599-601
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi

Harrison W Gabel
Gary Ruvkun
Research27 Apr 2008
Nature Structural & Molecular Biology

Volume: 15, P: 531-533
Author Correction: Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans

J. Amaranath Govindan
Elamparithi Jayamani
Gary Ruvkun
Amendments and Corrections11 Apr 2022
Nature Cell Biology

Volume: 24, P: 1005-1007
Correction: Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

Eyleen J. O'Rourke
Gary Ruvkun
Amendments and Corrections23 Dec 2014
Nature Cell Biology

Volume: 17, P: 104
Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease

Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed symptoms, even after they began, suggesting that hypoxia may protect neurons.

Eizo Marutani
Maria Miranda
Fumito Ichinose
ResearchOpen Access06 Aug 2025
Nature Neuroscience

Volume: 28, P: 1858-1867
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7

Sylvia E. J. Fischer
Maurice D. Butler
Gary Ruvkun
Research10 Sept 2008
Nature

Volume: 455, P: 491-496
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

Although the soma ages during life, the germ line of multicellular organisms does not. Here it is shown that Caenorhabditis elegans mutants with increased longevity turn on gene expression programs in somatic tissue that are normally limited to the germ line; this may be the secret behind the increased health and lifespan of these mutant worms.

Sean P. Curran
Xiaoyun Wu
Gary Ruvkun
Research07 Jun 2009
Nature

Volume: 459, P: 1079-1084
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans

Scott Kennedy
Duo Wang
Gary Ruvkun
Research12 Feb 2004
Nature

Volume: 427, P: 645-649
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

Kaveh Ashrafi
Francesca Y. Chang
Gary Ruvkun
Research16 Jan 2003
Nature

Volume: 421, P: 268-272
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant

Ji Ying Sze
Martin Victor
Gary Ruvkun
Research03 Feb 2000
Nature

Volume: 403, P: 560-564
Polygenic control of Caenorhabditis elegans fat storage

Ho Yi Mak
Laura S Nelson
Gary Ruvkun
Research05 Feb 2006
Nature Genetics

Volume: 38, P: 363-368
The perfect storm of tiny RNAs

Gary Ruvkun
Comments & Opinion01 Oct 2008
Nature Medicine

Volume: 14, P: 1041-1045
Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification

The molybdenum cofactor (Moco) is required for survival to mitigate sulfite toxicity. Genetic studies in C. elegans reveal that Moco-biosynthetic mutants are able to survive if Moco is provided through the microbial diet.

Kurt Warnhoff
Gary Ruvkun
Research25 Mar 2019
Nature Chemical Biology

Volume: 15, P: 480-488
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Siu Sylvia Lee
Raymond Y.N. Lee
Gary Ruvkun
Research25 Nov 2002
Nature Genetics

Volume: 33, P: 40-48
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

Brenda J. Reinhart
Frank J. Slack
Gary Ruvkun
Research24 Feb 2000
Nature

Volume: 403, P: 901-906
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Scott Ogg
Suzanne Paradis
Gary Ruvkun
Research30 Oct 1997
Nature

Volume: 389, P: 994-999
RNAi screening for fat regulatory genes with SRS microscopy

Stimulated Raman scattering (SRS) microscopy is a quantitative, label-free imaging method to map fat distribution and accumulation with high spatial resolution and sensitivity at both cellular and organism levels.

Meng C Wang
Wei Min
X Sunney Xie
Research16 Jan 2011
Nature Methods

Volume: 8, P: 135-138
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Amy E. Pasquinelli
Brenda J. Reinhart
Gary Ruvkun
Research02 Nov 2000
Nature

Volume: 408, P: 86-89
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

Jennifer H Mansfield
Brian D Harfe
Michael T McManus
Research12 Sept 2004
Nature Genetics

Volume: 36, P: 1079-1083
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants

Duo Wang
Scott Kennedy
Gary Ruvkun
Research28 Jul 2005
Nature

Volume: 436, P: 593-597
Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans

A screen identifies 15 genes that modulate CUG-repeat toxicity in C. elegans, including those encoding RNA-export and clearance factors. Toxic RNAs are recognized by the NMD pathway via their 3' UTR GC content.

Susana M D A Garcia
Yuval Tabach
Gary Ruvkun
Research20 Jul 2014
Nature Structural & Molecular Biology

Volume: 21, P: 712-720
Nanopore sequencing at Mars, Europa, and microgravity conditions

Christopher E. Carr
Noelle C. Bryan
Maria T. Zuber
ResearchOpen Access07 Sept 2020
npj Microgravity

Volume: 6, P: 1-6
Don't hold your breath

In some organisms a reduced-calorie diet increases lifespan. Conventional thinking about the mechanism involved now comes under question from the results of experiments with yeast.

Siu Sylvia Lee
Gary Ruvkun
News & Views18 Jul 2002
Nature

Volume: 418, P: 287-288
Breaking the silence

Gary Ruvkun
Books & Arts01 May 2004
Nature Genetics

Volume: 36, P: 435
Systematic analysis of genes required for synapse structure and function

Derek Sieburth
QueeLim Ch'ng
Joshua M. Kaplan
Research28 Jul 2005
Nature

Volume: 436, P: 510-517
DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

The transcription factor DAF-16/FOXO is a downstream effector of insulin/insulin-like growth factor signaling and plays an important role in stress resistance and longevity. Here, the authors show that DAF-16/FOXO can form a complex with HLH-30/TFEB to synergistically regulate transcription of target genes in response to certain stress stimuli.

Xin-Xuan Lin
Ilke Sen
Christian G. Riedel
ResearchOpen Access23 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Metabolic regulation of species-specific developmental rates

An in vitro system that recapitulates temporal characteristics of embryonic development demonstrates that the different rates of mouse and human embryonic development stem from differences in metabolic rates and—further downstream—the global rate of protein synthesis.

Margarete Diaz-Cuadros
Teemu P. Miettinen
Olivier Pourquié
Research04 Jan 2023
Nature

Volume: 613, P: 550-557
New motif in PBX genes

Thomas R. Bürglin
Gary Ruvkun
Correspondence01 Aug 1992
Nature Genetics

Volume: 1, P: 319-320
An image analysis toolbox for high-throughput C. elegans assays

The freely available WormToolbox enables high-throughput image analysis of a variety of phenotypes of Caenorhabditis elegans in liquid culture and should prove useful for image-based screens.

Carolina Wählby
Lee Kamentsky
Anne E Carpenter
Research22 Apr 2012
Nature Methods

Volume: 9, P: 714-716
Acceleration profiles and processing methods for parabolic flight

Christopher E. Carr
Noelle C. Bryan
Maria T. Zuber
ResearchOpen Access07 Aug 2018
npj Microgravity

Volume: 4, P: 1-5
Endogenous small interfering RNAs in animals

An endogenous small interfering RNA (endo-siRNA) pathway had only previously been characterized in worms. The recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in flies and mice raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.

Katsutomo Okamura
Eric C. Lai
Reviews01 Sept 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 673-678
Oncomirs — microRNAs with a role in cancer

MicroRNAs (miRNAs) are small, non-protein-coding RNAs that can repress the expression of important cancer-related genes. The mutation or mis-expression of several miRNAs is evident in human cancers, so will these novel RNAs prove useful in the diagnosis and treatment of cancer?

Aurora Esquela-Kerscher
Frank J. Slack
Reviews01 Apr 2006
Nature Reviews Cancer

Volume: 6, P: 259-269
Small non-coding RNAs in animal development

Our understanding of the biological functions of small non-coding RNAs has been fostered by the analysis of genetic deletions of individual microRNAs (miRNAs) in mammals. These studies show that miRNAs are key regulators of animal development and are potential human disease loci.

Giovanni Stefani
Frank J. Slack
Reviews01 Mar 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 219-230
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

MicroRNAs (miRNAs) are small non-coding RNAs that can modulate mRNA expression. Insights into the roles of miRNAs in development and disease have led to the development of new therapeutic approaches that are based on miRNA mimics or agents that inhibit their functions (antimiRs), and the first such approaches have entered the clinic. This Review discusses the role of different miRNAs in cancer and other diseases, and provides an overview of current miRNA therapeutics in the clinic.

Rajesha Rupaimoole
Frank J. Slack
Reviews17 Feb 2017
Nature Reviews Drug Discovery

Volume: 16, P: 203-222
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

Many different microRNAs (miRNAs) have now been linked to cancer, but our understanding of the pathways that are regulated by these miRNAsin vivois still limited. This Review discusses progress in using mouse models to understand the roles of miRNAs in cancer and the therapeutic potential of these molecules.

Andrea L. Kasinski
Frank J. Slack
Reviews24 Nov 2011
Nature Reviews Cancer

Volume: 11, P: 849-864

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