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Showing 1–4 of 4 results
Advanced filters: Author: Gavriel Mullokandov Clear advanced filters

  • Replication of the hepatitis C virus (HCV) requires a host RNA molecule, miR-122, whose transient inhibition is being explored as an antiviral therapy. Here, the authors study the interaction between miR-122 and HCV, and identify mutations in HCV strains that affect susceptibility to miR-122 inhibition.

    • Benjamin Israelow
    • Gavriel Mullokandov
    • Matthew J. Evans
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • Two large-scale resources for studying microRNA function are presented: one is a library of fluorescent sensors with a corresponding assay for global profiling of microRNA activity in different cell types; the other is a decoy library for suppressing microRNA activity individually or in pooled loss-of-function screens.

    • Gavriel Mullokandov
    • Alessia Baccarini
    • Brian D Brown
    Research
    Nature Methods
    Volume: 9, P: 840-846

  • Random and targeted mutagenesis of serum paraoxonase, coupled with the development of a screen that allows detection of enzymatic activity against the toxic isomer of cyclosarin, yielded a mutant enzyme capable of protecting mice from a lethal dose of this dangerous nerve agent.

    • Rinkoo D Gupta
    • Moshe Goldsmith
    • Dan S Tawfik
    Research
    Nature Chemical Biology
    Volume: 7, P: 120-125

  • Ovarian cancer is often diagnosed at a late stage when metastasis has already occurred. In this study, Parikh et al.show that mir-181a is involved in mediating the epithelial-to-mesenchymal transition in ovarian cancer, leading to activation of the TGF-β signalling pathway and metastasis.

    • Aditya Parikh
    • Christine Lee
    • Analisa DiFeo
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-16