Nature Search

Pre-assembly of biomolecular condensate seeds drives RSV replication

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Dhanushika Ratnayake
Marie Galloux
Marvin E. Tanenbaum
ResearchOpen Access28 Jan 2026
Nature

P: 1-12
Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

Nazneen Rahman, Geert Kops and colleagues report the identification of biallelic loss-of-function mutations in TRIP13 in six individuals with Wilms tumor who presented with features of mosaic variegated aneuploidy. They show that TRIP13-mutant cells show spindle assembly checkpoint defects and suggest that mechanisms leading to aneuploidy may contribute directly to increased cancer risk.

Shawn Yost
Bas de Wolf
Nazneen Rahman
Research29 May 2017
Nature Genetics

Volume: 49, P: 1148-1151
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

The authors use three-dimensional live-cell imaging of colorectal carcinoma organoids to show that chromosomal instability is widespread. Single-cell sequencing identifies heterogeneity of copy number alterations and shows clonal evolution.

Ana C. F. Bolhaqueiro
Bas Ponsioen
Geert J. P. L. Kops
Research29 Apr 2019
Nature Genetics

Volume: 51, P: 824-834
Nuclear chromosome locations dictate segregation error frequencies

Using single-cell DNA sequencing after an error-prone mitosis in untransformed, diploid cell lines and organoids, chromosomes are shown to have different segregation error frequencies that result in non-random aneuploidy landscapes.

Sjoerd J. Klaasen
My Anh Truong
Geert J. P. L. Kops
ResearchOpen Access13 Jul 2022
Nature

Volume: 607, P: 604-609
DNA methylation influences human centromere positioning and function

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

Catalina Salinas-Luypaert
Danilo Dubocanin
Daniele Fachinetti
ResearchOpen Access04 Sept 2025
Nature Genetics

Volume: 57, P: 2509-2521
Degree and site of chromosomal instability define its oncogenic potential

Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely dependent on both its extent and anatomical location.

Wilma H. M. Hoevenaar
Aniek Janssen
Nannette Jelluma
ResearchOpen Access20 Mar 2020
Nature Communications

Volume: 11, P: 1-11
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

Saurin, Kops and colleagues suggest that rapid spindle assembly checkpoint (SAC) responsiveness is mediated by a mechanism in which active SAC recruits PP2A, leading to PP1 recruitment, which in turn displaces PP2A and shuts off the SAC.

Wilco Nijenhuis
Giulia Vallardi
Adrian T. Saurin
Research17 Nov 2014
Nature Cell Biology

Volume: 16, P: 1257-1264
Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

The spindle assembly checkpoint protects against premature chromosome segregation during mitosis but it is not known whether microtubule attachment to the kinetochore, or force generated from this interaction, is being monitored. Here the authors uncouple these processes and show that microtubule attachment is sufficient to satisfy the checkpoint.

Banafsheh Etemad
Timo E. F. Kuijt
Geert J. P. L. Kops
ResearchOpen Access01 Dec 2015
Nature Communications

Volume: 6, P: 1-8
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

Mitotic exit is controlled by a cell division checkpoint that prevents premature degradation of cyclin B by the anaphase-promoting complex. Saurinet al. show that Aurora B directly regulates timely establishment of this checkpoint by facilitating activation of Mps1 kinase at unattached kinetochores.

Adrian T. Saurin
Maike S. van der Waal
Geert J.P.L. Kops
ResearchOpen Access17 May 2011
Nature Communications

Volume: 2, P: 1-9
Molecular characterization of colorectal cancer related peritoneal metastatic disease

Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct molecular subtype.

Kristiaan J. Lenos
Sander Bach
Louis Vermeulen
ResearchOpen Access04 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

Sacristan et al. show that the dynein adaptor Spindly facilitates oligomerisation of the RZZ complex to expand the kinetochore, after which Spindly-associated dynein compacts the kinetochore to allow for faithful chromosome segregation.

Carlos Sacristan
Misbha Ud Din Ahmad
Geert JPL Kops
Research18 Jun 2018
Nature Cell Biology

Volume: 20, P: 800-810
Direct control of the Forkhead transcription factor AFX by protein kinase B

Geert J. P. L. Kops
Nancy D. de Ruiter
Boudewijn M. Th. Burgering
Research15 Apr 1999
Nature

Volume: 398, P: 630-634
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Geert J. P. L. Kops
Tobias B. Dansen
Boudewijn M. T. Burgering
Research19 Sept 2002
Nature

Volume: 419, P: 316-321
Chromosomal copy number heterogeneity predicts survival rates across cancers

Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal instability and can predict pan-cancer survival.

Erik van Dijk
Tom van den Bosch
Daniël M. Miedema
ResearchOpen Access27 May 2021
Nature Communications

Volume: 12, P: 1-12
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Analysis of live-cell imaging and single-cell genome sequencing data of colorectal cancer organoids identifies temporal dynamics of sub-chromosomal copy-number amplifications.

Yannik Bollen
Ellen Stelloo
Hugo J. G. Snippert
ResearchOpen Access01 Jul 2021
Nature Genetics

Volume: 53, P: 1187-1195
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27^kip1

René H. Medema
Geert J. P. L. Kops
Boudewijn M. T. Burgering
Research13 Apr 2000
Nature

Volume: 404, P: 782-787
Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

The mechanisms for replicating and segregating DNA are highly conserved across eukaryotes. A comparative genomic analysis of a free-living protist finds a surprising lack of protein complexes involved in these processes, suggesting that the organism uses alternative mechanisms to process DNA.

Dayana E. Salas-Leiva
Eelco C. Tromer
Andrew J. Roger
ResearchOpen Access14 Oct 2021
Nature Communications

Volume: 12, P: 1-13
Sequential cancer mutations in cultured human intestinal stem cells

Using the CRISPR/Cas9 system, up to four frequently occurring colorectal cancer mutations were introduced alone or in combination into stem cell organoids derived from human small intestinal or colon tissue, allowing an in-depth investigation of the contribution of these mutations to cancer progression.

Jarno Drost
Richard H. van Jaarsveld
Hans Clevers
Research29 Apr 2015
Nature

Volume: 521, P: 43-47
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

Nicholas Kwiatkowski
Nannette Jelluma
Nathanael S Gray
Research11 Apr 2010
Nature Chemical Biology

Volume: 6, P: 359-368
On the road to cancer: aneuploidy and the mitotic checkpoint

Geert J. P. L. Kops
Beth A. A. Weaver
Don W. Cleveland
Reviews01 Oct 2005
Nature Reviews Cancer

Volume: 5, P: 773-785
Author Correction: Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

Dayana E. Salas-Leiva
Eelco C. Tromer
Andrew J. Roger
Amendments and CorrectionsOpen Access16 Dec 2021
Nature Communications

Volume: 12, P: 1-6
BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer

Prashanthi Ramesh
Tamsin R. M. Lannagan
Jan Paul Medema
ResearchOpen Access11 Jun 2021
Cell Death & Differentiation

Volume: 28, P: 3282-3296
Principles and dynamics of spindle assembly checkpoint signalling

The spindle assembly checkpoint (SAC) ensures correct chromosome segregation during mitosis by inhibiting anaphase until all kinetochores are attached to microtubules. Recent studies highlight the dynamic properties of SAC signalling and begin to explain signal integration at mammalian kinetochores, which feature multiple attachment points.

Andrew D. McAinsh
Geert J. P. L. Kops
Reviews24 Mar 2023
Nature Reviews Molecular Cell Biology

Volume: 24, P: 543-559

Search

Pre-assembly of biomolecular condensate seeds drives RSV replication

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Nuclear chromosome locations dictate segregation error frequencies

DNA methylation influences human centromere positioning and function

Degree and site of chromosomal instability define its oncogenic potential

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

Molecular characterization of colorectal cancer related peritoneal metastatic disease

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

Direct control of the Forkhead transcription factor AFX by protein kinase B

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Chromosomal copy number heterogeneity predicts survival rates across cancers

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27^kip1

Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

Sequential cancer mutations in cultured human intestinal stem cells

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

On the road to cancer: aneuploidy and the mitotic checkpoint

Author Correction: Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer

Principles and dynamics of spindle assembly checkpoint signalling

Search

Quick links

Search

Filter By:

Search

Quick links