Loss of IL-33 in a murine model of retinopathy reduces pathological retinal neovascularization, which can be specified to the role of IL-33 in endothelial cells. IL-33 induces sprouting angiogenesis, and it requires NFkappaB-mediated Jagged 1 expression and Notch1 activation.
- Deepti Sharma
- Shivantika Bisen
- Nikhlesh K. Singh