Pioneer transcription factors such as Foxa1 and Foxa2 need to bind to nucleosomal DNA to regulate chromatin structure and gene activation. Now a genome-wide nucleosome mapping in mouse liver shows that the maintenance of nucleosome position and chromatin structure surrounding Foxa23 binding sites is independent of Foxa1/2.
- Zhaoyu Li
- Jonathan Schug
- Klaus H Kaestner
