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Mutational landscape influences immunotherapy outcomes among patients with non-small-cell lung cancer with human leukocyte antigen supertype B44

Garon and colleagues demonstrate that the association of HLA supertype B44 with response to immune checkpoint blockade in melanoma but not NSCLC is related to differential mutational features that influence HLA binding of neoepitopes.

Amy L. Cummings
Jaklin Gukasyan
Edward B. Garon
Research16 Nov 2020
Nature Cancer

Volume: 1, P: 1167-1175
A screen of Crohn’s disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells

Yu-Ling Chang
Maura Rossetti
Jonathan Braun
Research25 Apr 2018
Mucosal Immunology

Volume: 12, P: 457-467

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Mutational landscape influences immunotherapy outcomes among patients with non-small-cell lung cancer with human leukocyte antigen supertype B44

A screen of Crohn’s disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells

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