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Showing 1–6 of 6 results
Advanced filters: Author: Genevieve R. Nemeth Clear advanced filters

  • A newly developed maternally selective nanobody antagonist against the angiotensin II type I receptor stabilizes the receptor in a hybrid conformation and simultaneously binds with specific small-molecule antagonists.

    • Meredith A. Skiba
    • Sarah M. Sterling
    • Andrew C. Kruse
    Research
    Nature Chemical Biology
    Volume: 20, P: 1577-1585

  • Off-target binding hinders the development of therapeutic antibodies and reproducibility in basic research settings. Here the authors develop a method to quantify and reduce the polyreactivity of antibody fragments based on protein sequence alone.

    • Edward P. Harvey
    • Jung-Eun Shin
    • Andrew C. Kruse
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Studies of the effect of sleep on learning and memory sometimes reveal conflicting or unreliable results. In this Perspective, Nemeth and colleagues review methodological challenges and make recommendations for improving the reliability of research in this field.

    • Dezső Németh
    • Emilie Gerbier
    • Karolina Janacsek
    Reviews
    Nature Reviews Psychology
    Volume: 3, P: 123-137