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Showing 1–2 of 2 results
Advanced filters: Author: Genevieve Saphier Clear advanced filters

  • The generation of human cell lines using somatic cell nuclear transfer has been difficult to achieve. In this study, Egliet al. show that while mouse eggs reprogram somatic cells within hours, human eggs arrest after nuclear transfer which may be due to a lack of genome transcription.

    • Dieter Egli
    • Alice E. Chen
    • Kevin Eggan
    Research
    Nature Communications
    Volume: 2, P: 1-10

  • The authors surveyed whole-exome and RNA-sequencing data from 252 unique pluripotent stem cell lines, some of which are in the pipeline for clinical use, and found that approximately 5% of cell lines had acquired mutations in the TP53 gene that allow mutant cells to rapidly outcompete non-mutant cells, but do not prevent differentiation.

    • Florian T. Merkle
    • Sulagna Ghosh
    • Kevin Eggan
    Research
    Nature
    Volume: 545, P: 229-233