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Showing 1–3 of 3 results
Advanced filters: Author: Geniver El Tekle Clear advanced filters

  • Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render prostate tumor cells sensitive to antiandrogen therapy and that the presence of ERG promotes sensitivity to high dose of androgen and SPOP inhibition.

    • Tiziano Bernasocchi
    • Geniver El Tekle
    • Jean-Philippe P. Theurillat
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Different mutations found in endometrial and prostate tumors affecting the substrate-recognition domain of SPOP, a component of the E3 ubiquitin ligase complex, result in opposing degradation activity of BET proteins and response to BET inhibitors. This work, along with findings by Zhang et al. and Dai et al., highlights the divergent effects of recurrent mutations affecting different residues within the same functional domain of SPOP and provides scientific rationale to guide the administration of BET inhibitors in endometrial and prostate cancer patients harboring SPOP mutations.

    • Hana Janouskova
    • Geniver El Tekle
    • Jean-Philippe P Theurillat
    Research
    Nature Medicine
    Volume: 23, P: 1046-1054

  • The role of the microbiota in tumorigenesis has garnered considerable attention over the past two decades. In this Review, El Tekle and Garrett explore the current and evolving understanding of microbiota in cancers of various internal organs, as well as highlighting opportunities for targeting bacteria for cancer prevention, diagnostics and treatment.

    • Geniver El Tekle
    • Wendy S. Garrett
    Reviews
    Nature Reviews Cancer
    Volume: 23, P: 600-618