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Showing 1–4 of 4 results
Advanced filters: Author: Geoff Dumsday Clear advanced filters

  • Gene dosage-based expression upregulation suffers from instability and random gene integration. Here, the authors report HapAmp, a method that uses haploinsufficiency as evolutionary force to drive in vivo gene amplification, and demonstrate its applications in protein and biochemical production in yeast.

    • Bingyin Peng
    • Lygie Esquirol
    • Claudia E. Vickers
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Cellular heterogeneity in cell populations of isogenic origin is driven by diverse factors such as nutrient availability and interactions with neighbouring cells. Here, Hu et al. study plasmid retention dynamics in yeast populations, and show that the exchange of complementary metabolites between plasmid-carrying prototrophs and plasmid-free auxotrophs allows the latter to proliferate in selective environments.

    • Kevin K. Y. Hu
    • Ankita Suri
    • Victoria S. Haritos
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Loss-of-function experiments are used in metabolic engineering to understand and optimise metabolism. Here, the authors apply auxin inducible protein degradation to test different metabolic engineering strategies for improved terpenoid production in yeast.

    • Zeyu Lu
    • Bingyin Peng
    • Claudia E. Vickers
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13