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Showing 1–4 of 4 results
Advanced filters: Author: Geoffrey von Maltzahn Clear advanced filters

  • Nanomaterials that can circulate in the body hold great potential to diagnose and treat disease, but suffer from problems such as toxicity. Porous silicon nanoparticles have now been engineered to concomitantly image tumours or organs within the body, deliver therapeutics and resorb in vivo into benign components that clear renally.

    • Ji-Ho Park
    • Luo Gu
    • Michael J. Sailor
    Research
    Nature Materials
    Volume: 8, P: 331-336

  • Here, the authors characterize the gut microbiome fermentation properties and therapeutic potential of chemically diverse synthetic glycans (SGs), showing they promote specific shifts in taxonomic and metabolite profiles, and exhibit therapeutic benefits in mouse models of colonic inflammation, together implying SGs as a potential avenue to treat disease by modulating the composition and metabolites produced by the gut microbiome.

    • Andrew C. Tolonen
    • Nicholas Beauchemin
    • Johan E. T. van Hylckama Vlieg
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • A two-component nanoparticle system that communicates and enhances in vivo drug delivery and diagnostics has been devised. The system comprises ‘signalling’ nanoparticles that target tumours and then broadcast the tumour’s location to ’receiving’ nanoparticles in circulation, which carry therapeutic or diagnostic cargos, hence amplifying tumour targeting.

    • Geoffrey von Maltzahn
    • Ji-Ho Park
    • Sangeeta N. Bhatia
    Research
    Nature Materials
    Volume: 10, P: 545-552