Nature Search

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

Georg A. Holländer
Baoping Wang
Cox Terhorst
Research26 Jan 1995
Nature

Volume: 373, P: 350-353
Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation

Effective CD8⁺ T cell immunity requires the generation of a long-lived memory pool and the maintenance of a non-exhausted effector T cell pool. The implementation of immune checkpoint blockade can reduced levels of exhaustion but lacks the ability to support memory formation in the effector pool. Here the authors suggest a role for Let-7 in the enhancement of the anti-tumor CD8⁺ T cell response by supporting memory via modulation of metabolic and differentiation state.

Alexandria C. Wells
Kaito A. Hioki
Leonid A. Pobezinsky
ResearchOpen Access11 Sept 2023
Nature Communications

Volume: 14, P: 1-15
The molecular nature of the cystic fibrosis antigen

JOSEF BRüGGEN
LAJOS TARCSAY
CLEMENS SORG
Research18 Feb 1988
Nature

Volume: 331, P: 570
RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy

RANK promotes the hormone-mediated development of thymic regulatory T cells during pregnancy; loss of RANK is associated with impaired maturation of maternal regulatory T cells, leading to fetal loss and the development of gestational diabetes.

Magdalena Paolino
Rubina Koglgruber
Josef M. Penninger
Research23 Dec 2020
Nature

Volume: 589, P: 442-447
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

T cell development requires functionally diverse thymic epithelial cell (TEC) populations performing specific functions. Here, using massively parallel flow cytometry and machine learning, the authors examine in mice the TEC compartment from the perinatal period to adulthood, identify novel phenotypic markers and characterize the function of perinatal cortical TEC.

Fabian Klein
Clara Veiga-Villauriz
Georg A. Holländer
ResearchOpen Access10 Jul 2023
Nature Communications

Volume: 14, P: 1-16
β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

Simona Frigerio
Tobias Junt
Luca Piali
Research04 Nov 2002
Nature Medicine

Volume: 8, P: 1414-1420
Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configuration, reduces TEC functions, reveals a specific TEC subset, and hampers T cell development.

Thomas Barthlott
Adam E. Handel
Georg A. Holländer
ResearchOpen Access24 Jun 2021
Nature Communications

Volume: 12, P: 1-19
Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan

Wedemeyer et al. find that age-associated waning of T-cell responses to infection and tolerance to self are regulated by a dynamic paracrine FGF21 signaling axis modulating mTORC1 and mTORC2 activity in thymic epithelial cells in mice.

Sarah A. Wedemeyer
Nicholas E. Jones
Ann V. Griffith
Research19 Feb 2025
Nature Aging

Volume: 5, P: 588-606
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

Holländer and colleagues provide a map of genes that are direct targets of the transcription factor Foxn1 in thymic epithelial cells and show that Foxn1 controls genes encoding products involved in thymocyte development, antigen processing and thymocyte selection.

Saulius Žuklys
Adam Handel
Georg A Holländer
Research22 Aug 2016
Nature Immunology

Volume: 17, P: 1206-1215
A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

Double-positive αβ thymocytes undergo negative selection on thymic epithelial cells. Ziegler and colleagues show that TGF-β limits numbers and function of medullary thymic epithelial cells, thus influencing the resultant T cell repertoire.

Mathias Hauri-Hohl
Saulius Zuklys
Steven F Ziegler
Research13 Apr 2014
Nature Immunology

Volume: 15, P: 554-561
Embryonic keratin19⁺ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla

Although the importance of thymic epithelial cells (TEC) in thymus physiology is established, the development of functionally diverse TEC populations remains incompletely understood. Here, using fate-mapping experiments in the embryonic thymus, the authors identify keratin19⁺ multipotent progenitor cells that support medullary TEC diversity in adulthood.

Beth Lucas
Andrea J. White
Graham Anderson
ResearchOpen Access12 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Nanoscale magnonic Fabry-Pérot resonator for low-loss spin-wave manipulation

Compared to electromagnetic waves, the wavelength of spin waves is significantly shorter at gigahertz frequencies, enabling the miniaturisation of wave-based devices. Here, the authors present a magnonic Fabry-Pérot resonator allowing for nanoscale and reconfigurable manipulation of spin waves.

Huajun Qin
Rasmus B. Holländer
Sebastiaan van Dijken
ResearchOpen Access16 Apr 2021
Nature Communications

Volume: 12, P: 1-10
Claudins provide a breath of fresh Aire

'Promiscuous' gene expression in medullary thymic epithelial cells positive for the autoimmune regulator Aire is critical for central T cell tolerance. Expression of the tight-junction components claudin-3 and claudin-4 'marks' Aire⁺ epithelial cells in the postnatal thymus and their direct precursors in the embryo.

Georg A Holländer
News & Views01 Mar 2007
Nature Immunology

Volume: 8, P: 234-236
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

Gina Balciunaite
Marcel P. Keller
Georg A. Holländer
Research15 Oct 2002
Nature Immunology

Volume: 3, P: 1102-1108
The transcriptional landscape of age in human peripheral blood

Ageing increases the risk of many diseases. Here the authors compare blood cell transcriptomes of over 14,000 individuals and identify a set of about 1,500 genes that are differently expressed with age, shedding light on transcriptional programs linked to the ageing process and age-associated diseases.

Marjolein J. Peters
Roby Joehanes
Andrew D. Johnson
ResearchOpen Access22 Oct 2015
Nature Communications

Volume: 6, P: 1-14
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.

Alexander Teumer
Layal Chaker
Marco Medici
ResearchOpen Access26 Oct 2018
Nature Communications

Volume: 9, P: 1-14
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
Generation of a complete thymic microenvironment by MTS24⁺ thymic epithelial cells

Jason Gill
Mark Malin
Richard Boyd
Research17 Jun 2002
Nature Immunology

Volume: 3, P: 635-642
Helicobacter pylori colonization and obesity – a Mendelian randomization study

Wouter J. den Hollander
Linda Broer
Ernst J. Kuipers
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-7
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

Mark A. Daniels
Emma Teixeiro
Ed Palmer
Research01 Nov 2006
Nature

Volume: 444, P: 724-729
In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

RNA regulatory elements (RREs) are important post-transcriptional control features but studying them requires disrupting their activity without disturbing cellular homeostasis. Here the authors present GenERA, a CRISPR-Cas9 screening platform of in situ analysis of native RREs.

Qianxin Wu
Quentin R. V. Ferry
Tudor A. Fulga
ResearchOpen Access13 Dec 2017
Nature Communications

Volume: 8, P: 1-17
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

Interferon-α is a critical mediator of pathogen-induced thymic involution. Liston and colleagues show that the microRNA miR-29a reduces sensitivity of thymic epithelium to infection signals and protects against thymus involution.

Aikaterini S Papadopoulou
James Dooley
Adrian Liston
Research18 Dec 2011
Nature Immunology

Volume: 13, P: 181-187
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a failed antigenic response to intestinal helminths.

Bergithe E. Oftedal
Stefano Maio
Georg A. Holländer
ResearchOpen Access03 Jun 2021
Communications Biology

Volume: 4, P: 1-14
The role of thymic tolerance in CNS autoimmune disease

In this Review, Handel and colleagues examine the contribution of thymic T cell selection to CNS autoimmune conditions and consider how a better understanding of this contribution could lead to novel therapeutic strategies for these conditions.

Adam E. Handel
Sarosh R. Irani
Georg A. Holländer
Reviews19 Nov 2018
Nature Reviews Neurology

Volume: 14, P: 723-734
[¹²³I]-β-CIT SPECT Imaging Shows Reduced Thalamus–Hypothalamus Serotonin Transporter Availability in 24 Drug-Free Obsessive-Compulsive Checkers

Werner Zitterl
Martin Aigner
Kenneth Thau
Research27 Dec 2006
Neuropsychopharmacology

Volume: 32, P: 1661-1668
Changes in Thalamus–Hypothalamus Serotonin Transporter Availability during Clomipramine Administration in Patients with Obsessive–Compulsive Disorder

Werner Zitterl
Martin Aigner
Kenneth Thau
Research19 Mar 2008
Neuropsychopharmacology

Volume: 33, P: 3126-3134
Long-term effects of medical management on growth and weight in individuals with urea cycle disorders

Roland Posset
Sven F. Garbade
Maja Djordjevic
ResearchOpen Access20 Jul 2020
Scientific Reports

Volume: 10, P: 1-13

Search

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation

The molecular nature of the cystic fibrosis antigen

RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy

The power of genetic diversity in genome-wide association studies of lipids

Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

Embryonic keratin19⁺ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla

Nanoscale magnonic Fabry-Pérot resonator for low-loss spin-wave manipulation

Claudins provide a breath of fresh Aire

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

The transcriptional landscape of age in human peripheral blood

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Generation of a complete thymic microenvironment by MTS24⁺ thymic epithelial cells

Helicobacter pylori colonization and obesity – a Mendelian randomization study

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

The role of thymic tolerance in CNS autoimmune disease

[¹²³I]-β-CIT SPECT Imaging Shows Reduced Thalamus–Hypothalamus Serotonin Transporter Availability in 24 Drug-Free Obsessive-Compulsive Checkers

Changes in Thalamus–Hypothalamus Serotonin Transporter Availability during Clomipramine Administration in Patients with Obsessive–Compulsive Disorder

Long-term effects of medical management on growth and weight in individuals with urea cycle disorders

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