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Showing 1–11 of 11 results
Advanced filters: Author: Georg Gasteiger Clear advanced filters

  • ILCs are considered preformed effector cells. Gasteiger and colleagues report that ILC1s undergo effector differentiation after lineage commitment. Hobit+ ILC1s emerge as cKit+TCF-1hi cells that generate tissue-specific helper- and cytotoxic-like cells along a Hobit-dependent trajectory.

    • Christin Friedrich
    • Renske L. R. E. Taggenbrock
    • Georg Gasteiger
    Research
    Nature Immunology
    Volume: 22, P: 1256-1267

  • MYC drives S-phase progression and immune invasion in pancreatic ductal adenocarcinoma (PDAC), but the underlying mechanisms are not fully understood. Here, the authors show that the transcription elongation complex PAF1c controls the competition of different gene sets for RNA polymerase and elongation factors to regulate these MYC-associated mechanisms in PDAC.

    • Abdallah Gaballa
    • Anneli Gebhardt-Wolf
    • Martin Eilers
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Recent evidence indicates that adaptive T cell-mediated immune responses can regulate innate lymphocytes (natural killer cells and innate lymphoid cells) in an interleukin-2-dependent manner. The authors propose a model in which adaptive T cells function as peripheral antigen-specific sensors that recruit and activate innate lymphocytes to amplify and coordinate local immune responses.

    • Georg Gasteiger
    • Alexander Y. Rudensky
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 631-639

  • BATF3 is a member of the AP-1 transcription factor family. Kastenmüller and colleagues show that BATF3 is needed to promote memory CD8+ T cell responses. Activated CD8+ T cells transiently upregulate BATF3, which in turn suppresses expression of proapoptotic BIM to promote cell survival.

    • Marco A. Ataide
    • Karl Komander
    • Wolfgang Kastenmüller
    Research
    Nature Immunology
    Volume: 21, P: 1397-1407

  • Single-cell transcriptomic and epigenetic analysis has enabled the identification of Thetis cells, a class of RORγt+ antigen-presenting cells with a key role in the differentiation of commensal microbiota-induced peripheral regulatory T cells.

    • Blossom Akagbosu
    • Zakieh Tayyebi
    • Chrysothemis C. Brown
    ResearchOpen Access
    Nature
    Volume: 610, P: 752-760

  • In studies using mouse models of psoriasis, a spectrum of innate lymphoid cell types is reconfigured and converges via multiple trajectories on a type 3-like state, demonstrating the range and flexibility of innate lymphoid cell responses in the skin.

    • Piotr Bielecki
    • Samantha J. Riesenfeld
    • Richard A. Flavell
    Research
    Nature
    Volume: 592, P: 128-132

  • Exposure to multiple pathogens is common in nature, yet interactions between the immune components targeting bacterial and viral pathogens during co-infection are poorly understood. Here the authors show that bacteria-derived LPS induces cytotoxic NK cells that suppress antiviral CD8 T cell response.

    • Tobias Straub
    • Marina A. Freudenberg
    • Hanspeter Pircher
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • The cytokine receptor IL-2R is essential for the development of Treg cells; therefore, it has been difficult to separate this from its role in the suppressive function of Treg cells. Rudensky and colleagues use various genetic systems to show that capture of IL-2 by IL-2R is important for suppression of CD8+ T cells but not that of CD4+ T cells.

    • Takatoshi Chinen
    • Arun K Kannan
    • Alexander Y Rudensky
    Research
    Nature Immunology
    Volume: 17, P: 1322-1333

  • Bedoui and colleagues discuss the naive state of conventional T cells as an actively repressed condition that supports T cell diversity and enables the flexible differentiation of effectors, and also offers a relevant discrimination criterion between innate and adaptive lymphocytes.

    • Sammy Bedoui
    • Thomas Gebhardt
    • Wolfgang Kastenmüller
    Reviews
    Nature Immunology
    Volume: 17, P: 490-494