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Showing 1–5 of 5 results
Advanced filters: Author: George E. Ghanim Clear advanced filters

  • To maintain genome stability, the specialised reverse transcriptase telomerase processively adds telomeric DNA repeats to chromosome ends. Here the authors reported structures of human telomerase at three stages of telomeric repeat synthesis, providing key insights into its mechanism.

    • Sebastian Balch
    • Elsa Franco-Echevarría
    • Thi Hoang Duong Nguyen
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • Here the authors captured the structure of human telomerase H/ACA ribonucleoprotein (RNP) by cryo-EM. The structure rationalizes telomere-disorder disease mutations and reveals insights into the mechanism of pseudouridylation by eukaryotic H/ACA RNPs.

    • George E. Ghanim
    • Zala Sekne
    • Thi Hoang Duong Nguyen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • A high-resolution structure of human telomerase bound to telomeric DNA reveals details of telomerase assembly and its active site, and sheds light on how mutations alter telomerase function.

    • George E. Ghanim
    • Adam J. Fountain
    • Thi Hoang Duong Nguyen
    Research
    Nature
    Volume: 593, P: 449-453

  • The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

    • Fan Bu
    • Yagoub Adam
    • Zhichao Miao
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 399-411