Juli Bai et al. demonstrate that overexpression of DsbA-L or knockout of STING in adipocytes protects mice against high-fat diet-induced obesity. They find that inhibition of the cGAS-STING pathway in adipocytes activates thermogenesis. This study presents the cGAS-STING pathway as a potential target for anti-obesity therapeutics.
- Juli Bai
- Christopher Cervantes
- Feng Liu
