Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and dysregulation of this process leads to ataxia and other diseases. Here the authors show that the LIM-homeodomain transcription factors Lhx1 and Lhx5 govern dendritogenesis and dendritic spine morphogenesis in postnatal PCs through regulating Espin expression.
- Nga Chu Lui
- Wing Yip Tam
- Kin Ming Kwan
