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Scientific Reports (2)
Nature Chemical Biology (1)

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Showing 1–3 of 3 results

Advanced filters: Author: Gerald Gavory Clear advanced filters

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

A selective inhibitor of the deubiquitinase USP7 binds an allosteric site to inhibit its MDM2-stabilizing activity, resulting in stabilization of p53 and p21, which confers hypersensitivity to cancer cells for killing by the compound.

Gerald Gavory
Colin R O'Dowd
Timothy Harrison
Research04 Dec 2017
Nature Chemical Biology

Volume: 14, P: 118-125
Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

Leanne Stevenson
Lauren Cairns
Richard C. Turkington
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development

Natalie Page
Mark Wappett
Timothy Harrison
ResearchOpen Access20 Sept 2022
Scientific Reports

Volume: 12, P: 1-14