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Advanced filters: Author: Gerald Hofstätter Clear advanced filters

  • The folate pathway enzyme MTHFD1 is recruited to chromatin by BRD4. Inhibition of BRD4 or MTHFD1 similarly changes nuclear metabolite composition and gene expression, and dual inhibition synergistically impairs cancer cell viability.

    • Sara Sdelci
    • André F. Rendeiro
    • Stefan Kubicek
    Research
    Nature Genetics
    Volume: 51, P: 990-998