Nature Search

Sizes of Retinal Images formed by Distant Objects

GERALD H. FISHER
Research08 Feb 1969
Nature

Volume: 221, P: 584-586
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Here, Hanke et al. immunize an alpaca with SARS-CoV-2 spike protein domains and identify a nanobody that binds the receptor binding domain of spike in both the up and down conformations and sterically hinders ACE2 engagement.

Leo Hanke
Laura Vidakovics Perez
Gerald M. McInerney
ResearchOpen Access04 Sept 2020
Nature Communications

Volume: 11, P: 1-9
A CD4⁺ T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease

William H H Reece
Margaret Pinder
Adrian V S Hill
Research14 Mar 2004
Nature Medicine

Volume: 10, P: 406-410
LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages

Targeted nanodrug delivery is crucial to treat respiratory diseases, but profiling the delivery and dynamics of nanoparticles (NPs) within the lung is a challenging task. Here, the authors present LungVis 1.0, an AI-driven 3D imaging ecosystem to profile inhaled substances in distinct lung regions while uncovering the role of tissue-resident macrophages in the fate of NPs.

Lin Yang
Qiongliang Liu
Otmar Schmid
ResearchOpen Access27 Nov 2024
Nature Communications

Volume: 15, P: 1-22
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell state that precedes the regeneration of AT1 cells and persists in human lung fibrosis.

Maximilian Strunz
Lukas M. Simon
Herbert B. Schiller
ResearchOpen Access16 Jul 2020
Nature Communications

Volume: 11, P: 1-20
Seventy-five genetic loci influencing the human red blood cell

A series of genetic studies have led to the discovery of novel independent loci and candidate genes associated with red blood cell phenotype; for a proportion of these genes potential single-nucleotide genetic variants are also identified, providing new insights into genetic pathways controlling red blood cell formation, function and pathology.

Pim van der Harst
Weihua Zhang
John C. Chambers
Research05 Dec 2012
Nature

Volume: 492, P: 369-375
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

Here, the authors isolate several nanobodies from a synthetic library that bind the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (S) and neutralize S pseudotyped viruses. Cryo-EM structure of Spike with one nanobody and further biophysical analysis shows competition with ACE2 binding.

Tânia F. Custódio
Hrishikesh Das
Christian Löw
ResearchOpen Access04 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Beyond PI3Ks: targeting phosphoinositide kinases in disease

The potential of therapeutically targeting phosphoinositide kinases (PIKs) beyond the class I PI3Ks is increasingly being realized. Here, Burke et al. describe the structure, function, regulation and roles in disease of all clinically relevant PIKs outside of the class I PI3Ks, assessing potent and specific small-molecule inhibitors in development.

John E. Burke
Joanna Triscott
Gerald R. V. Hammond
Reviews14 Nov 2022
Nature Reviews Drug Discovery

Volume: 22, P: 357-386

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Sizes of Retinal Images formed by Distant Objects

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

A CD4⁺ T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease

LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

Seventy-five genetic loci influencing the human red blood cell

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

Beyond PI3Ks: targeting phosphoinositide kinases in disease

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