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Showing 1–5 of 5 results
Advanced filters: Author: Geraldine Gentric Clear advanced filters

  • Features of the stroma and immune infiltrate in patients with invasive lobular breast carcinoma (ILC) have been associated with poor prognosis. Here the authors report that E-cadherin loss in ILC cancer cells influences cancer associated fibroblast differentiation and spatial organization of tumor-infiltrating lymphocytes, resulting in immune escape and poor prognosis.

    • Lounes Djerroudi
    • Rana Mhaidly
    • Fatima Mechta-Grigoriou
    ResearchOpen Access
    Nature Communications
    P: 1-23

  • An important contribution of cancer associated fibroblasts (CAFs) in regulating chemoresistance has been reported. Here the authors investigate the impact of chemotherapy on CAF subsets in patients with high-grade serous ovarian cancer, suggesting that residual ANTXR1+ myofibroblasts are associated with inhibition of anti-tumor immunity.

    • Monika Licaj
    • Rana Mhaidly
    • Fatima Mechta-Grigoriou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-27

  • Patients with estrogen receptor positive breast cancer (ER + BC) treated with palbociclib (CDK4/6 inhibitor) frequently develop resistance. Here, the authors identify a reliance of palbociclib resistance on oxidative phosphorylation (OXPHOS) and therapeutically target this vulnerability using an OXPHOS inhibitor, restoring sensitivity in ER + BC preclinical models.

    • Rania El-Botty
    • Ludivine Morriset
    • Elisabetta Marangoni
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL12β.

    • Anne-Marie Givel
    • Yann Kieffer
    • Fatima Mechta-Grigoriou
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-20