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Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors

This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity without reducing on-target potency.

Jose Cabezas-Caballero
Anna Huhn
Omer Dushek
ResearchOpen Access02 Jan 2026
Nature Biomedical Engineering

P: 1-12
Large clonal expansions of CD8⁺ T cells in acute infectious mononucleosis

Margaret F.C. Callan
Neil Steven
Andrew J. McMichael
Research01 Aug 1996
Nature Medicine

Volume: 2, P: 906-911
Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Lucy C. Walters
Karl Harlos
Geraldine M. Gillespie
Amendments and CorrectionsOpen Access13 Nov 2018
Nature Communications

Volume: 9, P: 1
Memory CD8⁺ T cells vary in differentiation phenotype in different persistent virus infections

Victor Appay
P. Rod Dunbar
Sarah L. Rowland-Jones
Research01 Apr 2002
Nature Medicine

Volume: 8, P: 379-385
Tetrameric HLA class I–minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

Tuna Mutis
Geraldine Gillespie
Els Goulmy
Research01 Jul 1999
Nature Medicine

Volume: 5, P: 839-842
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Human leucocyte antigen E (HLA-E) directly engages NK cells but also presents antigen to CD8⁺ T cells. Here the authors show crystal structures of HLA-E in complex with peptides derived from HIV and Mycobacterium tuberculosis, and describe binding conformations, the positional impact of residues involved and discuss implications for functional presentation to CD8⁺ T cells.

Lucy C. Walters
Karl Harlos
Geraldine M. Gillespie
ResearchOpen Access07 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

A study shows that cross-reactivity of microbial antigens and self-antigens presented by HLA-B*27 may be important in the pathogenesis of diseases associated with HLA-B*27 and identifies the shared binding motif responsible.

Xinbo Yang
Lee I. Garner
K. Christopher Garcia
Research07 Dec 2022
Nature

Volume: 612, P: 771-777
Publisher Correction: High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

Brooke D. Huisman
Ning Guan
Michael E. Birnbaum
Amendments and CorrectionsOpen Access29 Aug 2023
Nature Communications

Volume: 14, P: 1
Adaptive meets innate: CD8⁺ T cells kill MHC-I-negative tumour cells

A preprint by Lerner et al. shows that conventional CD8⁺ T cells can kill tumour cells lacking MHC class I expression in an NKG2D-dependent manner.

Bas W. A. Peeters
Geraldine M. Gillespie
Research Highlights29 Mar 2023
Nature Reviews Immunology

Volume: 23, P: 272
HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses

Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C receptors. Carrington and colleagues provide comprehensive analysis of classical HLA class I SP variants and show that these can determine CD94/NKG2–HLA-E engagement.

Zhansong Lin
Arman A. Bashirova
Mary Carrington
Research01 Jun 2023
Nature Immunology

Volume: 24, P: 1087-1097
High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

HLA-E is a highly conserved MHC-l recognized by NK and T cells. The authors characterize HLA-E-presented peptides recognized by CD94/NKG2x, identifying human and CMV-derived peptide ligands which can modulate NK cell activity when presented by HLA-E, including for selective NK cell activation.

Brooke D. Huisman
Ning Guan
Michael E. Birnbaum
ResearchOpen Access09 Aug 2023
Nature Communications

Volume: 14, P: 1-13
Targeting MHC-E as a new strategy for vaccines and immunotherapeutics

The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new, universally effective vaccines and immunotherapies for infectious disease and cancer that are independent of the MHC haplotype of an individual.

Klaus Früh
Persephone Borrow
Louis J. Picker
Reviews03 Sept 2025
Nature Reviews Immunology

Volume: 26, P: 52-66
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

The identification and structural analysis of HLA-E-VL9-targeting antibodies that block a natural killer (NK) cell receptor pathway and regulate NK function in vitro.

Dapeng Li
Simon Brackenridge
Barton F. Haynes
ResearchOpen Access28 Mar 2022
Communications Biology

Volume: 5, P: 1-17
Characterization of triatomine bloodmeal sources using direct Sanger sequencing and amplicon deep sequencing methods

Sujata Balasubramanian
Rachel Curtis-Robles
Sarah A. Hamer
ResearchOpen Access17 Jun 2022
Scientific Reports

Volume: 12, P: 1-11

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