Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–14 of 14 results
Advanced filters: Author: Geraldine Seydoux Clear advanced filters

  • PAR polarity proteins are asymmetrically localized at the cortex of Caenorhabditis elegans zygotes. Seydoux and colleagues show that aPKC-mediated phosphorylation of PAR-2, which inhibits recruitment of PAR-2 to the cortex, is directly inhibited by microtubules emanating from the sperm-donated centrosomes. This protection allows PAR-2, and subsequently the PAR-1 kinase to access the cortex nearby the sperm, thus defining the posterior of the embryo. PAR-1 in turn phosphorylates PAR-3 to induce dissociation of PAR-3–aPKC from the posterior.

    • Fumio Motegi
    • Seth Zonies
    • Geraldine Seydoux
    Research
    Nature Cell Biology
    Volume: 13, P: 1361-1367

  • Ouyang et al. show that the RNA helicase ZNFX-1 preserves heritable RNAi by maintaining a pool of small RNA-targeted transcripts in perinuclear condensates of the Caenorhabditis elegans germline, which serve as templates for small-RNA amplification in the next generation.

    • John Paul Tsu Ouyang
    • Wenyan Lucy Zhang
    • Geraldine Seydoux
    ResearchOpen Access
    Nature Cell Biology
    Volume: 24, P: 1129-1140

  • Genome sequencing and RNAi have been powerful allies in the quest to assign function to every gene. Systematic RNAi screens identify essential genes efficiently, but are less effective with pleiotropic or redundant genes. A common trick used by geneticists to overcome this problem is to screen for genetic interactors — mutations that enhance or suppress the phenotype of a starting mutation. Now, this classic approach has been combined with the versatility of RNAi to generate an expanded gene network for cell polarity.

    • Geraldine Seydoux
    News & Views
    Nature Cell Biology
    Volume: 15, P: 9-10

  • Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.

    • Chih-Yung Lee
    • Geraldine Seydoux
    News & Views
    Nature Cell Biology
    Volume: 21, P: 116-117

  • Epigenetic inheritance is the transfer of non-DNA information across generations. A new study identifies sperm-specific PEI granules as essential for paternal epigenetic inheritance. PEI granule partitioning to sperm requires palmitoylation and myosin VI activity, suggesting lipidation-dependent granule transport on vesicles.

    • Laura Thomas
    • Geraldine Seydoux
    News & Views
    Nature Cell Biology
    Volume: 24, P: 129-130

  • Loss-of-function (LOF) approaches are powerful experimental tools for characterizing gene functions. However, emerging discrepancies when genes are investigated using different tools or organisms has triggered debate about how such LOF results should be biologically interpreted. In this Review, experts from varied fields discuss how understanding the underlying features of each LOF approach can provide explanations for different experimental outcomes and can guide their optimal and reliable application.

    • Benjamin E. Housden
    • Matthias Muhar
    • Norbert Perrimon
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 24-40

  • It is shown here that the methylation of histone proteins regulates lifespan in Caenorhabditis elegans. Deficiencies in members of the ASH-2 complex, which trimethylates histone H3 at lysine 4 (H3K4), extend worm lifespan. Meanwhile, the H3K4 demethylase RBR-2 is required for normal lifespan. These findings are consistent with the idea that an excess of H3K4 trimethylation reduces longevity. The extension of lifespan caused by ASH-2 deficiency requires an intact adult germline and the continuous production of mature eggs.

    • Eric L. Greer
    • Travis J. Maures
    • Anne Brunet
    Research
    Nature
    Volume: 466, P: 383-387

  • A new method, SENTINEL, improves the specificity of nucleic acid target sequence identification via a combination of isothermal amplification and sequence-specific DNA endonucleases. The method can discriminate single base-pair differences and takes less than 1 h to complete.

    • Roger S. Zou
    • Momcilo Gavrilov
    • Taekjip Ha
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-9