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Showing 1–4 of 4 results

Advanced filters: Author: Gerard Joey Broussard Clear advanced filters

Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning

Subpopulations of Purkinje neurons display distinct transcriptomic responses and functions in associative learning.

Xiaoying Chen
Yanhua Du
Azad Bonni
Research11 May 2022
Nature

Volume: 605, P: 722-727
In vivo measurement of afferent activity with axon-specific calcium imaging

The authors introduce a variant GCaMP that is targeted to axons. Due to its strong brightness, signal-to-noise ratio, and photostability, this tool, named axon-GCaMP, enables robust Ca²⁺ imaging in individual axons, including in vivo in awake mice.

Gerard Joey Broussard
Yajie Liang
Lin Tian
Research20 Aug 2018
Nature Neuroscience

Volume: 21, P: 1272-1280
Fast and sensitive GCaMP calcium indicators for imaging neural populations

Using large-scale screening and structure-guided mutagenesis, fast and sensitive GCaMP sensors are developed and optimized with improved kinetics without compromising sensitivity or brightness.

Yan Zhang
Márton Rózsa
Loren L. Looger
ResearchOpen Access15 Mar 2023
Nature

Volume: 615, P: 884-891
Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators

This protocol describes how to redesign, characterize, validate and apply genetically encoded dopamine sensors, such as those of the dLight1 family, to measure dopamine transients in cultured cells, neurons, acute brain slices and freely behaving, awake mice.

Tommaso Patriarchi
Jounhong Ryan Cho
Lin Tian
Protocols15 Nov 2019
Nature Protocols

Volume: 14, P: 3471-3505