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Showing 1–5 of 5 results
Advanced filters: Author: Gerard Minuesa Clear advanced filters

  • The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.

    • Gerard Minuesa
    • Steven K. Albanese
    • Michael G. Kharas
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • In mammals there are two Musashi proteins, MSI1 and MSI2, orthologues of the Drosophila protein, with roles in asymmetric stem cell division and cell fate determination. Here the authors report new functions for MSI2 in colorectal cancer using in vitro loss of function and in vivoectopic overexpression.

    • Shan Wang
    • Ning Li
    • Christopher J. Lengner
    Research
    Nature Communications
    Volume: 6, P: 1-15

  • MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain of CBP/P300 and inhibits leukaemia growth.

    • Kavitha Ramaswamy
    • Lauren Forbes
    • Alex Kentsis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Michael Kharas and colleagues characterize the MSI2 protein interactome in leukemia cells and subsequently perform a functional screen identifying 24 genes required for leukemia in vivo. They focus on the RNA-binding protein SYNCRIP, showing that it regulates Hoxa9 and other transcripts involved in a myeloid leukemia stem cell program.

    • Ly P Vu
    • Camila Prieto
    • Michael G Kharas
    Research
    Nature Genetics
    Volume: 49, P: 866-875