Barrachina et al. present an extensive lipidomic analysis at different stages of thrombopoiesis and, through in vitro and in vivo experiments, demonstrate that fatty acid uptake, largely dependent on the scavenger receptor CD36, and its regulation are essential for megakaryocyte maturation and platelet production.
- Maria N. Barrachina
- Gerard Pernes
- Kellie R. Machlus