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Pyrazinamide triggers degradation of its target aspartate decarboxylase

It has been shown that the bioactive component of pyrazinamide, pyrazinoic acid (POA), blocks coenzyme A biosynthesis in M. tuberculosis by binding to the aspartate decarboxylase PanD. Here the authors show that pyrazinamide triggers degradation of PanD by stimulating its degradation by the caseinolytic protease Clp.

Pooja Gopal
Jickky Palmae Sarathy
Thomas Dick
ResearchOpen Access03 Apr 2020
Nature Communications

Volume: 11, P: 1-10
Targeting the Mycobacterium ulcerans cytochrome bc₁:aa₃ for the treatment of Buruli ulcer

Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success. Here, the authors show that a clinical-stage drug candidate for tuberculosis, Q203, is effective at killing M. ulcerans and is a promising therapeutic candidate for BU.

Nicole Scherr
Raphael Bieri
Kevin Pethe
ResearchOpen Access18 Dec 2018
Nature Communications

Volume: 9, P: 1-9
Barnacle cement protein as an efficient bioinspired corrosion inhibitor

Metallic surfaces are often coated with corrosion inhibitors to prevent damage but these are typically toxic to the environment. Here, a recombinant adhesive cement protein from barnacles is shown to effectively protect steel against corrosion under marine environment conditions.

My Hanh Bui
Shu Hui Hiew
Ali Miserez
ResearchOpen Access23 Feb 2024
Communications Materials

Volume: 5, P: 1-15
Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils

Bhuvaneswari Kannaian
Bhargy Sharma
Konstantin Pervushin
ResearchOpen Access29 Aug 2019
Scientific Reports

Volume: 9, P: 1-17
Molecular mechanism of the Escherichia coli AhpC in the function of a chaperone under heat-shock conditions

Neelagandan Kamariah
Birgit Eisenhaber
Gerhard Grüber
ResearchOpen Access20 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

Wuan-Geok Saw
Mu-Lu Wu
Gerhard Grüber
ResearchOpen Access14 Nov 2019
Scientific Reports

Volume: 9, P: 1-15
Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport

Sreekanth Rajan
Minjoo Choi
Ho Sup Yoon
ResearchOpen Access29 May 2015
Scientific Reports

Volume: 5, P: 1-12
AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

Chui Fann Wong
Joon Shin
Gerhard Grüber
ResearchOpen Access11 Jul 2017
Scientific Reports

Volume: 7, P: 1-15
Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxins

Neelagandan Kamariah
Mun Foong Sek
Gerhard Grüber
ResearchOpen Access28 Nov 2016
Scientific Reports

Volume: 6, P: 1-15

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Pyrazinamide triggers degradation of its target aspartate decarboxylase

Targeting the Mycobacterium ulcerans cytochrome bc₁:aa₃ for the treatment of Buruli ulcer

Barnacle cement protein as an efficient bioinspired corrosion inhibitor

Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils

Molecular mechanism of the Escherichia coli AhpC in the function of a chaperone under heat-shock conditions

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxins

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