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Showing 1–4 of 4 results
Advanced filters: Author: Gerlinde Wernig Clear advanced filters

  • Abdominal adhesions are a common cause of bowel obstruction, but knowledge regarding adhesion biology and anti-adhesion therapies remains limited. Here the authors report a systematic analysis of mouse and human adhesion tissues demonstrating that visceral fibroblast JUN and associated PDGFRA expression promote adhesions, and JUN suppression can prevent adhesion formation.

    • Deshka S. Foster
    • Clement D. Marshall
    • Michael T. Longaker
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Maintaining proper reactive oxygen species (ROS) balance is critical for cellular and individual health, yet its dynamic nature encumbers monitoring and assessment. Here the authors propose a platform using mass cytometry-based detection, termed SN-ROP, to identify distinct ROS profiles associated with specific immune cell functions and disease states.

    • Yi-Chuan Wang
    • Ping-Hsun Wu
    • Shih-Yu Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Hematopoietic stem cell (HSC) transplantation is a desirable treatment for many non-malignant and malignant diseases, but its use requires preconditioning of recipients with irradiation or chemotherapy that often induces high toxicity. Here the authors show that antibody-drug-conjugate to CD117, a HSC marker, allows specific and efficient preconditioning for HSC therapy.

    • Agnieszka Czechowicz
    • Rahul Palchaudhuri
    • Derrick J. Rossi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Fibroblast contributions to lung fibrosis and in particular their crosstalk with immune cells in the lung are incompletely understood. Here, the authors show an overall immune suppressive environment transcriptionally controlled and maintained by fibroblasts in lung fibrosis with possible therapeutic implications.

    • Lu Cui
    • Shih-Yu Chen
    • Gerlinde Wernig
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14