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Showing 1–10 of 10 results
Advanced filters: Author: Gero Miesenböck Clear advanced filters
  • On the anniversary of the Boyden et al. (2005) paper that introduced the use of channelrhodopsin in neurons, Nature Neuroscience asks selected members of the community to comment on the utility, impact and future of this important technique.

    • Antoine Adamantidis
    • Silvia Arber
    • Rachel I Wilson
    Comments & Opinion
    Nature Neuroscience
    Volume: 18, P: 1202-1212
  • Sleep-promoting neurons in Drosophila are shown to switch between electrical activity and silence as a function of sleep need; the switch is operated by dopamine and involves the antagonistic regulation of two potassium channels.

    • Diogo Pimentel
    • Jeffrey M. Donlea
    • Gero Miesenböck
    Research
    Nature
    Volume: 536, P: 333-337
  • Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

    • Raffaele Sarnataro
    • Cecilia D. Velasco
    • Gero Miesenböck
    ResearchOpen Access
    Nature
    Volume: 645, P: 722-728
  • Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state of a stably bound NADPH cofactor.

    • H. Olof Rorsman
    • Max A. Müller
    • Gero Miesenböck
    ResearchOpen Access
    Nature
    Volume: 641, P: 232-239
  • The rate at which third-order olfactory neurons integrate synaptic inputs to spike threshold is thought to determine the speed of odor discrimination in Drosophila. Here, authors compare the impact of subthreshold optogenetic membrane potential manipulations on decision-making.

    • Timothy L. H. Wong
    • Clifford B. Talbot
    • Gero Miesenböck
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9
  • GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development,Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex.

    • Paul G. Anastasiades
    • Andre Marques-Smith
    • Simon J. B. Butt
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13
  • There are thought to be canonical patterns of connectivity between excitatory neurons of different layers within a column, but whether such patterns exist for inhibitory connectivity remained unclear. Here the authors identify stereotypical connectivity motifs across M1, V1 and S1, but find that their abundance varies among regions and cell types.

    • Dennis Kätzel
    • Boris V Zemelman
    • Gero Miesenböck
    Research
    Nature Neuroscience
    Volume: 14, P: 100-107
  • Sparse coding is thought to facilitate pattern separation for associative memory, but behavioral evidence is scant. The authors show that in Drosophila, feedback inhibition enforces sparse odor coding in Kenyon cells, the neurons that store olfactory associations. Disrupting this sparsening mechanism impairs learned discrimination of similar, but not dissimilar, odors.

    • Andrew C Lin
    • Alexei M Bygrave
    • Gero Miesenböck
    Research
    Nature Neuroscience
    Volume: 17, P: 559-568
  • Sleep deprivation in Drosophila elevates reactive oxygen species in sleep-promoting neurons, leading to changes in potassium currents and spiking activity and thereby connecting energy metabolism, oxidative stress, and sleep.

    • Anissa Kempf
    • Seoho M. Song
    • Gero Miesenböck
    Research
    Nature
    Volume: 568, P: 230-234