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Showing 1–3 of 3 results
Advanced filters: Author: Giada Mondanelli Clear advanced filters

  • 3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.

    • Cristina C. Clement
    • Angelo D’Alessandro
    • Laura Santambrogio
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology.

    • Alessandra Fiore
    • Stefano Ugel
    • Vincenzo Bronte
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Indoleamine 2,3-dioxygenase 1 (IDO1) is crucial in cancer-related immunosuppression, yet its signaling function remains underexplored in immunotherapy development. Here, the authors use second harmonic generation analysis and molecular dynamics simulations to reveal that clinical IDO1 inhibitors differentially modulate its signaling, impacting distinct transcriptomes.

    • Alice Coletti
    • Elisa Bianconi
    • Antonio Macchiarulo
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-12