FOXO proteins are transcription factors that regulate responses to stress stimuli to maintain cellular homeostasis. The deregulation of FOXO protein functions plays a role in cardiovascular disease, cancer, diabetes and neurological diseases. This Review summarizes the biology of FOXO proteins and their functions in disease and longevity and discusses the pharmacological approaches to develop FOXO-targeting therapeutics.
- Giampaolo Calissi
- Eric W.-F. Lam
- Wolfgang Link
