Nature Search

Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

Marco Gerling
Nikè V.J.A. Büller
Rune Toftgård
Amendments and CorrectionsOpen Access13 Sept 2016
Nature Communications

Volume: 7, P: 1-2
NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

James CH Hardwick
Gijs R van den Brink
Maikel P Peppelenbosch
Research09 Apr 2001
Oncogene

Volume: 20, P: 819-827
Bone morphogenetic protein signalling in colorectal cancer

Mutations in the bone morphogenetic protein pathway have been found in juvenile polyposis, an inherited polyposis syndrome that predisposes to colorectal cancer. What relevance do these findings have to sporadic cases of colorectal cancer?

James C. Hardwick
Liudmila L. Kodach
Gijs R. van den Brink
Reviews29 Aug 2008
Nature Reviews Cancer

Volume: 8, P: 806-812
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

Gijs R van den Brink
Sylvia A Bleuming
Maikel P Peppelenbosch
Research08 Feb 2004
Nature Genetics

Volume: 36, P: 277-282
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

CRISPR base editing technologies can be used for disease modelling. Here the authors use various base editing tools to generate tumour models in human adult stem cell-derived hepatocyte, endometrial and intestinal organoids.

Maarten H. Geurts
Shashank Gandhi
Hans Clevers
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-18
Blimp1 regulates the transition of neonatal to adult intestinal epithelium

Many mammals are born with an immature intestinal epithelium, which adapts to a changing diet during the weaning period. Muncanet al. show that the transcriptional repressor Blimp1is expressed in the intestine of mice at birth, and that expression is lost at the transition to the weaning stage.

Vanesa Muncan
Jarom Heijmans
Gijs R. van den Brink
ResearchOpen Access30 Aug 2011
Nature Communications

Volume: 2, P: 1-9
Epithelial calcineurin controls microbiota-dependent intestinal tumor development

The intestinal microbiota signals through epithelial cells to activate calcineurin and NFAT, driving proliferation of cancer stem cells and the development of colorectal cancer.

Kenneth Peuker
Stefanie Muff
Sebastian Zeissig
Research04 Apr 2016
Nature Medicine

Volume: 22, P: 506-515
FcαRI co-stimulation converts human intestinal CD103⁺ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

Dendritic cells (DC) are important for maintaining immune homeostasis in the gut, but how they promote intestinal inflammation upon bacterial infection is still unclear. Here the authors show that IgA immune complexes induce proinflammatory cytokine production by metabolic reprogramming of otherwise tolerogenic human CD103⁺ DCs.

Ivo S. Hansen
Lisette Krabbendam
Jeroen den Dunnen
ResearchOpen Access28 Feb 2018
Nature Communications

Volume: 9, P: 1-13
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling.

Marco Gerling
Nikè V. J. A. Büller
Rune Toftgård
ResearchOpen Access05 Aug 2016
Nature Communications

Volume: 7, P: 1-17
Linking pathways in colorectal cancer

Studies of inherited cancer syndromes have implicated numerous signaling pathways in colorectal carcinogenesis, but the relationship between these signaling pathways remains poorly understood. Now, a new mouse model of juvenile polyposis syndrome identifies a molecular mechanism for clonal epithelial cell expansion and links several pathways with an established role in polyposis.

Gijs R van den Brink
News & Views01 Oct 2004
Nature Genetics

Volume: 36, P: 1038-1039
Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation

Florien Westendorp
Olga N. Karpus
Gijs R. van den Brink
Research21 Jan 2021
Oncogene

Volume: 40, P: 1628-1643
Hh pathway expression in human gut tissues and in inflammatory gut diseases

Corinne M Nielsen
Jerrell Williams
Drucilla J Roberts
Research25 Oct 2004
Laboratory Investigation

Volume: 84, P: 1631-1642
Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis

Jonathan H. M. van der Meer
Ruben J. de Boer
Vanesa Muncan
ResearchOpen Access01 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-13
Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2

Bartolomeus J. Meijer
Wouter L. Smit
Jarom Heijmans
ResearchOpen Access10 May 2021
Scientific Reports

Volume: 11, P: 1-15
Compound heterozygous NEK1 variants in two siblings with oral-facial-digital syndrome type II (Mohr syndrome)

Glen R Monroe
Isabelle FPM Kappen
Gijs van Haaften
Research17 Aug 2016
European Journal of Human Genetics

Volume: 24, P: 1752-1760
Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling

Claudia N. Spaan
Wouter L. Smit
Jarom Heijmans
ResearchOpen Access21 Jun 2019
Cell Death & Disease

Volume: 10, P: 1-10

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Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

Bone morphogenetic protein signalling in colorectal cancer

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

Epithelial calcineurin controls microbiota-dependent intestinal tumor development

FcαRI co-stimulation converts human intestinal CD103⁺ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

Linking pathways in colorectal cancer

Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation

Hh pathway expression in human gut tissues and in inflammatory gut diseases

Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis

Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2

Compound heterozygous NEK1 variants in two siblings with oral-facial-digital syndrome type II (Mohr syndrome)

Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling

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