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Showing 1–9 of 9 results
Advanced filters: Author: Gil Gregor Westmeyer Clear advanced filters

  • This protocol for the use and quality control of genetically encoded reporters to label proteins and cells in correlative light and electron microscopy workflows enables the acquisition of molecular, cellular and biochemical information at high resolution.

    • Oleksandr Berezin
    • Alberto Piovesan
    • Gil Gregor Westmeyer
    Protocols
    Nature Protocols
    Volume: 21, P: 1705-1729

  • Exo-PE is an approach to improve prime editing efficacy for insertions while maintaining precision.

    • Dong-Jiunn Jeffery Truong
    • Julian Geilenkeuser
    • Gil Gregor Westmeyer
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 455-464

  • This perspective describes recent developments in genetically encoded protein contrast agents for non-invasive biological imaging, namely ultrasound, magnetic resonance and optoacoustic imaging modalities.

    • Arash Farhadi
    • Felix Sigmund
    • Mikhail G. Shapiro
    Reviews
    Nature Materials
    Volume: 20, P: 585-592

  • Bioluminescence imaging with enhanced sensitivity, resolution and dynamic range is enabled by a camera based on quanta image sensor technology in combination with a dedicated unconventional microscope design. The capabilities of the QIScope are demonstrated in live imaging of extracellular vesicles or low-abundance proteins.

    • Ruyu Ma
    • Luciano M. Santino
    • Jian Cui
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 1321-1330

  • Mitochondrial dysfunction is a contributing factor in Parkinson’s disease. Here the authors carry out a multilayered omics analysis of Parkinson’s disease patient-derived neuronal cells, which reveals a reversible hypometabolism mediated by α-ketoglutarate dehydrogenase deficiency, which is correlated with disease progression in the donating patients.

    • Sebastian Schmidt
    • Constantin Stautner
    • Wolfgang Wurst
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-24

  • Truong et al. developed a cell-based reporter system, EXSISERS, that enables non-invasive quantification of the protein expression levels of exon-specific isoforms via intein-mediated protein splicing.

    • Dong-Jiunn Jeffery Truong
    • Teeradon Phlairaharn
    • Gil Gregor Westmeyer
    ResearchOpen Access
    Nature Cell Biology
    Volume: 23, P: 652-663