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Showing 1–6 of 6 results
Advanced filters: Author: Gilles Bonvento Clear advanced filters

  • The molecular interplay between metabolic and synaptic functions of astrocytes is underexplored. Here, the authors show that astrocyte cannabinoid type-1 receptors integrate lactate and D-serine signaling to promote NMDA receptor-dependent cognition.

    • Ignacio Fernández-Moncada
    • Gianluca Lavanco
    • Giovanni Marsicano
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Previous studies on astrocyte development have led to controversial results due to a lack of pertinent tools. Here, authors analyze large numbers of astrocyte clones generated by nearby cortical progenitors using the MAGIC Markers strategy and ChroMS 3D imaging, and show that clonally-related astrocytes organize in a non-stereotyped manner and that cortical astrocyte subtypes are not intrinsically specified.

    • Solène Clavreul
    • Lamiae Abdeladim
    • Karine Loulier
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • In mice, persistent activation of mitochondrial cannabinoid receptors in astroglia impairs cellular glucose metabolism and lactate production, leading to an increase in redox stress in neurons and altered behavioural responses.

    • Daniel Jimenez-Blasco
    • Arnau Busquets-Garcia
    • Giovanni Marsicano
    Research
    Nature
    Volume: 583, P: 603-608

  • Neurons and astrocytes cooperate metabolically but differ in key aspects of their metabolism, including the production of mitochondrial reactive oxygen species (ROS). Here, the authors show that mitochondrial ROS produced in astrocytes affect neuronal metabolism and mouse memory and behaviour.

    • Carlos Vicente-Gutierrez
    • Nicoló Bonora
    • Juan P. Bolaños
    Research
    Nature Metabolism
    Volume: 1, P: 201-211

  • Good–bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.

    • Carole Escartin
    • Elena Galea
    • Alexei Verkhratsky
    Reviews
    Nature Neuroscience
    Volume: 24, P: 312-325