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Showing 1–5 of 5 results
Advanced filters: Author: Giorgia Manni Clear advanced filters

  • Ferriero et al. show that liver fibrosis reduces the efficiency of AAV-based gene therapy by limiting liver uptake and altering vector distribution to other organs. The impact of fibrosis varies depending on the AAV variant, highlighting the need for tailored approaches in fibrotic diseases.

    • Rosa Ferriero
    • Gemma Bruno
    • Pasquale Piccolo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • 3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.

    • Cristina C. Clement
    • Angelo D’Alessandro
    • Laura Santambrogio
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Influenza viremia is rare in human blood and not well studied. Here, the authors show that influenza can be found in human platelets and that platelet engulfment of influenza A results in TLR7-dependent C3 release, which in turn promotes neutrophil-DNA release and formation of platelet-DNA aggregates.

    • Milka Koupenova
    • Heather A. Corkrey
    • Jane E. Freedman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • Immunogenicity of AAV vectors renders repeated AAV dosing ineffective. Here the authors show that coadministration of nanoparticle-encapsulated rapamycin overcomes AAV immunogenicity through Treg induction, enabling efficient AAV redosing in mice and nonhuman primates.

    • Amine Meliani
    • Florence Boisgerault
    • Federico Mingozzi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13