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Showing 1–7 of 7 results
Advanced filters: Author: Giray Enkavi Clear advanced filters

  • Dumesnil et al. report that cholesterol esters (CE), which only melt above body temperature, form supercooled liquid crystalline lipid droplets (LD). Triacylglycerols (TG) solubilize CE to help CE LD nucleation. Through clustering TGs in the ER membrane, seipin controls CE LD nucleation sites.

    • Calvin Dumesnil
    • Lauri Vanharanta
    • Abdou Rachid Thiam
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Tail-anchored (TA) membrane protein biogenesis is mediated by the GET insertase. Here, authors present cryo-EM and X-ray structures, MD simulations and functional data for human and fungal insertases showing membrane remodeling for TA insertion.

    • Melanie A. McDowell
    • Michael Heimes
    • Irmgard Sinning
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the interface between terminal actin subunits.

    • Tommi Kotila
    • Hugo Wioland
    • Pekka Lappalainen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Moliner et al. show that psychedelics directly bind to the BDNF receptor TrkB with high affinity and promote BDNF-mediated plasticity and antidepressant-like effects, whereas their hallucinogenic-like effects are independent of TrkB binding.

    • Rafael Moliner
    • Mykhailo Girych
    • Eero Castrén
    ResearchOpen Access
    Nature Neuroscience
    Volume: 26, P: 1032-1041

  • Membrane transporters transition between inward- and outward-facing conformations to translocate substrates across membranes but mechanistic details of this process remain scarce. Here Moradiet al. use an advanced molecular simulation approach to describe the complete thermodynamic cycle of the GlpT transporter at atomic-level detail.

    • Mahmoud Moradi
    • Giray Enkavi
    • Emad Tajkhorshid
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Depolymerized ADP-actin monomers must be recharged with ATP for new rounds of filament assembly. Here the authors show that cyclase-associated protein (CAP) catalyzes actin nucleotide exchange in vivo and their CAP–actin complex structure reveals the molecular mechanism of CAP-mediated actin nucleotide exchange.

    • Tommi Kotila
    • Konstantin Kogan
    • Pekka Lappalainen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12