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Showing 1–2 of 2 results
Advanced filters: Author: Girma M. Woldemichael Clear advanced filters

  • There is lack of therapies targeting the PAX3-FOXO1 fusion oncogene in fusion-positive rhabdomyosarcoma (FP-RMS). Here, the authors identify and characterise an inhibitor with highest inhibition of histone lysine demethylase 3B that suppresses PAX3-FOXO1 activity in FP-RMS.

    • Yong Yean Kim
    • Berkley E. Gryder
    • Javed Khan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Core regulatory transcription factors are usually regulated by cell-type specific super enhancers (SEs). Here, the authors screen for chemical probes able to distinguish between SE-driven and promoter-driven transcription and find that histone deacetylases are selectively required for core regulatory transcription.

    • Berkley E. Gryder
    • Lei Wu
    • Javed Khan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12