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Recognition of bacterial glycosphingolipids by natural killer T cells

Yuki Kinjo
Douglass Wu
Mitchell Kronenberg
Research24 Mar 2005
Nature

Volume: 434, P: 520-525
IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis

Innate immune responses are regulated in the intestine to prevent excessive inflammation. Here the authors demonstrate a pivotal role for intestinal macrophages that constitutively produce IL-10 in controlling excessive innate immune activation and preventing tissue damage after an acute bacterial infection.

Petra Krause
Venetia Morris
Masako Murai
Research11 May 2015
Nature Communications

Volume: 6, P: 1-12
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

Interleukin 10–deficient mice develop spontaneous colitis. Kronenberg and colleagues find that interleukin 10 released by myeloid cells in the intestine is needed to maintain expression of the transcription factor Foxp3 in regulatory T cells.

Masako Murai
Olga Turovskaya
Mitchell Kronenberg
Research27 Sept 2009
Nature Immunology

Volume: 10, P: 1178-1184
Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

CD4⁺ and CD8⁺ T cells are considered distinct functional lymphocyte subsets. Cheroutre and Mucida and their colleagues show that mature gut-associated CD4⁺ T cells lose ThPOK expression and reactivate CD8 cytolytic effector programs.

Daniel Mucida
Mohammad Mushtaq Husain
Hilde Cheroutre
Research20 Jan 2013
Nature Immunology

Volume: 14, P: 281-289
Protein kinase C-η controls CTLA-4–mediated regulatory T cell function

Signaling events at the T_reg cell immune synapse remain unknown. Altman and colleagues show that a CTLA-4–PKC-η signaling axis is required for contact-dependent suppression by T_reg cells.

Kok-Fai Kong
Guo Fu
Amnon Altman
Research06 Apr 2014
Nature Immunology

Volume: 15, P: 465-472
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria

The TNF receptor HVEM is shown to control the innate immune response to pathogenic bacteria by regulating mucosal epithelial cells in the intestine and lung.

Jr-Wen Shui
Alexandre Larange
Mitchell Kronenberg
Research15 Jul 2012
Nature

Volume: 488, P: 222-225
Induction of effective antitumor immune responses in a mouse bladder tumor model by using DNA of an α antigen from mycobacteria

Isao Kuromatsu
Kazuhiro Matsuo
Yasuhiro Yasutomi
Research10 Aug 2001
Cancer Gene Therapy

Volume: 8, P: 483-490

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Recognition of bacterial glycosphingolipids by natural killer T cells

IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

Protein kinase C-η controls CTLA-4–mediated regulatory T cell function

HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria

Induction of effective antitumor immune responses in a mouse bladder tumor model by using DNA of an α antigen from mycobacteria

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Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes