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Showing 1–4 of 4 results
Advanced filters: Author: Giulia Tyzack Clear advanced filters

  • Perineuronal astrocyte reactivity is implicated in functional recovery following nerve injury but exactly how this happens is unclear. Tyzack et al. show that perineuronal astrocytes facilitate the recovery of synaptic inputs to damaged neurons via STAT3-dependent upregulation of the astrocytic protein TSP-1.

    • Giulia E. Tyzack
    • Sergey Sitnikov
    • András Lakatos
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-15

  • Intron retention (IR) can increase protein diversity and function, and yet unregulated IR may be detrimental to cellular health. This study shows that aberrant IR occurs in ALS and finds nuclear loss of an RNA-binding protein called SFPQ as a new molecular hallmark in this devastating condition.

    • Raphaelle Luisier
    • Giulia E. Tyzack
    • Rickie Patani
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated STAT3 activation, which is impaired in models of amyotrophic lateral sclerosis.

    • Giulia E. Tyzack
    • Claire E. Hall
    • András Lakatos
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17