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Cabozantinib and temozolomide in patients with advanced progressive neuroendocrine tumors: a phase 2 study

Treatment options for patients with advanced neuroendocrine tumors (NETs) are limited. Here this group reports a single-arm, phase 2 trial assessing the safety and efficacy of cabozantinib and metronomic temozolomide in patients with advanced, progressive, well-differentiated NETs of gastroenteropancreatic, pulmonary or unknown origin.

Mauro Cives
Giuseppina Della Vittoria Scarpati
Salvatore Tafuto
ResearchOpen Access10 Apr 2026
Nature Communications

P: 1-14
MiR-140-3p regulates axonal motor protein KIF5A and contributes to axonal transport degeneration in SMA

Markella Baklou
Valeria Valsecchi
Giuseppe Pignataro
ResearchOpen Access07 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-9
Combined ketone body and glutamine supplementation restores aerobic energy production in AGC1-deficient neuronal progenitors

Simona Nicole Barile
Maria Chiara Magnifico
Francesco Massimo Lasorsa
ResearchOpen Access15 Dec 2025
Cell Death & Disease

Volume: 17, P: 1-17
p63 in Laryngeal Squamous Cell Carcinoma: Evidence for a Role of TA-p63 Down-Regulation in Tumorigenesis and Lack of Prognostic Implications of p63 Immunoreactivity

Giancarlo Pruneri
Lorenzo Pignataro
Giuseppe Viale
Research01 Oct 2002
Laboratory Investigation

Volume: 82, P: 1327-1334
Correction: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke

Valeria Valsecchi
Giusy Laudati
Giuseppe Pignataro
Amendments and CorrectionsOpen Access31 Jul 2023
Cell Death & Disease

Volume: 14, P: 1
Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na⁺/Ca²⁺ exchanger 3 downregulation

Serenella Anzilotti
Paola Brancaccio
Giuseppe Pignataro
ResearchOpen Access12 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-17
The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke

Valeria Valsecchi
Giusy Laudati
Giuseppe Pignataro
ResearchOpen Access30 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-11
Heparan sulfate binding protein treatment ameliorates neuropathology and behavioral abnormalities in mucopolysaccharidosis IIIB mice

Serenella Anzilotti
Melania Scarcella
Valeria De Pasquale
ResearchOpen Access01 Aug 2025
Cell Death Discovery

Volume: 11, P: 1-10
Photobiomodulation-induced choriocapillaris perfusion enhancement and outer retinal remodelling in intermediate age-related macular degeneration: a promising therapeutic approach with short-term results

Pasquale Viggiano
Giacomo Boscia
Francesco Boscia
Research19 Apr 2025
Eye

Volume: 39, P: 2057-2063
Preconditioning in hypoxic-ischemic neonate mice triggers Na⁺-Ca²⁺ exchanger-dependent neurogenesis

P. Brancaccio
S. Anzilotti
G. Pignataro
ResearchOpen Access13 Jul 2022
Cell Death Discovery

Volume: 8, P: 1-11
SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

SMN deficiency causes age-dependent reduction of cerebral norepinephrine levels in mice by influencing the expression of genes regulating monoamine metabolism. In severe SMA1 patients, the SMN-inducing drug, Nusinersen, rescues CSF norepinephrine levels.

Valeria Valsecchi
Francesco Errico
Alessandro Usiello
ResearchOpen Access13 Nov 2023
Communications Biology

Volume: 6, P: 1-19
A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA

Daniela Pignataro
Sofia Francia
Alessandra Montecucco
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors

Concetta Di Mauro
Ada Pesapane
Roberto Bianco
ResearchOpen Access24 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype

S Anzilotti
M Tornincasa
G M Pierantoni
ResearchOpen Access03 Dec 2015
Cell Death & Disease

Volume: 6, P: e2004
Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system

Glymphatic and lymphatic communication contribute to the clearance of cerebrospinal fluid and the removal of macromolecules from the brain. Understanding the intricate mechanisms and the circadian influence might revolutionize treatment strategies.

Ester Licastro
Giuseppe Pignataro
Elga Esposito
ReviewsOpen Access24 Feb 2024
Communications Biology

Volume: 7, P: 1-9

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