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De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation

De novo mutations in MSL3 cause an X-linked syndrome affecting both males and females. MSL3 mutations reduce H4K16ac levels and lead to misregulation of cellular pathways involved in morphogenesis, cellular shape, and cell migration.

M. Felicia Basilicata
Ange-Line Bruel
Asifa Akhtar
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1442-1451
MAPCap allows high-resolution detection and differential expression analysis of transcription start sites

The position, shape and number of transcription start sites (TSS) regulate gene expression. Here authors present MAPCap, a method for high-resolution detection and differential expression analysis of TSS, and apply MAPCap to early fly development, detecting stage and sex-specific promoter and enhancer activity.

Vivek Bhardwaj
Giuseppe Semplicio
Asifa Akhtar
ResearchOpen Access30 Jul 2019
Nature Communications

Volume: 10, P: 1-15
Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells

In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly regulates mouse orthologues.

Claudia Isabelle Keller Valsecchi
M. Felicia Basilicata
Asifa Akhtar
ResearchOpen Access07 Sept 2018
Nature Communications

Volume: 9, P: 1-14
RNA nucleation by MSL2 induces selective X chromosome compartmentalization

Dosage compensation in Drosophila involves nucleation of the dosage compensation complex at the X chromosome by MSL2 and the non-coding RNA roX.

Claudia Isabelle Keller Valsecchi
M. Felicia Basilicata
Asifa Akhtar
Research18 Nov 2020
Nature

Volume: 589, P: 137-142

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De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation

MAPCap allows high-resolution detection and differential expression analysis of transcription start sites

Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells

RNA nucleation by MSL2 induces selective X chromosome compartmentalization

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