Bacterial two-component systems (TCSs) consist of a sensor histidine kinase (HK) and a response regulator that modulate gene expression. Here, the authors generate phosphatase-deficient HK mutants, with constitutive TCS activation, to characterise the regulatory networks of 14 TCSs in the human pathogen Streptococcus agalactiae.
- Cosme Claverie
- Francesco Coppolino
- Arnaud Firon
