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Showing 1–7 of 7 results
Advanced filters: Author: Glenn R. Bantug Clear advanced filters

  • Bantug and Hess discuss the metabolic interplay between tumor-resident cells and how the effect of metabolism-targeted anticancer strategies on non-transformed or immune cells in the tumor needs to be considered.

    • Glenn R. Bantug
    • Christoph Hess
    Reviews
    Nature Immunology
    Volume: 24, P: 2008-2020

  • Hess and colleagues perform metabolic screens in B cells from patients with primary antibody deficiency and find that germline mutations in the succinate dehydrogenase subunit SDHA drive the expression of the cytokine IL-6 in patients with persistent polyclonal B cell lymphocytosis.

    • Anne-Valérie Burgener
    • Glenn R. Bantug
    • Christoph Hess
    Research
    Nature Immunology
    Volume: 20, P: 1311-1321

  • Low availability of glucose in tumors negatively affects the activity of tumor-infiltrating T cells. Loss of T cell function under these conditions is mediated by the microRNAs miR-101 and miR-26a, which target expression of the methytransferase EZH2 and thereby diminish the expression of anti-tumor cytokines.

    • Glenn R Bantug
    • Christoph Hess
    News & Views
    Nature Immunology
    Volume: 17, P: 41-42

  • Here, the authors introduce the idea that a spectrum of metabolic states of immune cells can provide a basis for categorizing human diseases. They explore the metabolic and interlinked signalling requirements of T cells responding to acute infection and how metabolic reprogramming of T cells is linked to disease.

    • Glenn R. Bantug
    • Lorenzo Galluzzi
    • Christoph Hess
    Reviews
    Nature Reviews Immunology
    Volume: 18, P: 19-34

  • Ruffieux, Hess and colleagues analyze longitudinal phenotyping of patients with coronavirus disease 2019 to show that covariation of innate immune cell numbers, kynurenine metabolites and lipid metabolites influence the restoration of homeostasis, the risk of death and that of long COVID.

    • Hélène Ruffieux
    • Aimee L. Hanson
    • Christoph Hess
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 349-358