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Showing 1–3 of 3 results
Advanced filters: Author: Gonzalo Gonzalez-Paez Clear advanced filters

  • Here, the authors use cryo-EM to solve the structures of seven potent human antibodies, and demonstrate in vivo protection in a liver burden assay, using chimeric Plasmodium berghei sporozoites expressing Plasmodium falciparum circumsporozoite protein.

    • Gregory M. Martin
    • Jonathan L. Torres
    • Andrew B. Ward
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to understand in vivo protection of PfCSP-targeting antibodies.

    • Tossapol Pholcharee
    • David Oyen
    • Ian A. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Small molecules are powerful tools for investigating protein function, and can serve as leads for new therapeutics, but most human proteins lack known small-molecule ligands; here, a quantitative analysis of cysteine-reactive small-molecule fragments screened against thousands of proteins is reported.

    • Keriann M. Backus
    • Bruno E. Correia
    • Benjamin F. Cravatt
    Research
    Nature
    Volume: 534, P: 570-574